3-炔基吡啶-4-胺 | 1239605-12-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 3-炔基吡啶-4-胺
• 英文名称: 3-ethynylpyridin-4-amine
• 英文别名: 4-amino-3-ethynylpyridine；3-ethynyl-4-pyridinamine
• CAS: 1239605-12-9
• 化学式: C₇H₆N₂
• 分子量: 118.138
• InChiKey: BKNDBCLJFUKLAQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  38.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-炔基吡啶-4-胺 在 四氢吡咯 作用下， 以 水 为溶剂， 反应 0.25h， 以82%的产率得到5-氮杂吲哚
  参考文献：
  名称：

  Microwave-assisted synthesis of indole- and azaindole-derivatives in water via cycloisomerization of 2-alkynylanilines and alkynylpyridinamines promoted by amines or catalytic amounts of neutral or basic salts

  摘要：

  An efficient methodology is described and exploited for the preparation of differently substituted indoles and azaindoles via microwave-assisted cycloisomerization in water of 2-alkynylanilines and alkynylpyridinamines, which is promoted by catalytic amounts of neutral or basic salts or by stoichiometric weak organic bases. Good to high yields in the cyclization can be achieved for a variety of 2-amino (hetero)aryl alkynes. Reactions are run without any added metal catalyst. A comparison with the cycloisomerization conducted under conventional heating is also described. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.06.083
• 作为产物：
  描述：

  {[(3-三甲基硅烷基)乙炔基]-吡啶-4-基}胺 在 水 、 sodium hydroxide 作用下， 以 甲醇 为溶剂， 以388 mg的产率得到3-炔基吡啶-4-胺
  参考文献：
  名称：

  Microwave-assisted synthesis of indole- and azaindole-derivatives in water via cycloisomerization of 2-alkynylanilines and alkynylpyridinamines promoted by amines or catalytic amounts of neutral or basic salts

  摘要：

  An efficient methodology is described and exploited for the preparation of differently substituted indoles and azaindoles via microwave-assisted cycloisomerization in water of 2-alkynylanilines and alkynylpyridinamines, which is promoted by catalytic amounts of neutral or basic salts or by stoichiometric weak organic bases. Good to high yields in the cyclization can be achieved for a variety of 2-amino (hetero)aryl alkynes. Reactions are run without any added metal catalyst. A comparison with the cycloisomerization conducted under conventional heating is also described. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.06.083

文献信息

• Electrophilic MiniFrags Revealed Unprecedented Binding Sites for Covalent HDAC8 Inhibitors
  作者：Aaron B. Keeley、Aleksandra Kopranovic、Vincenzo Di Lorenzo、Péter Ábrányi-Balogh、Niklas Jänsch、Linh N. Lai、László Petri、Zoltán Orgován、Daniel Pölöske、Anna Orlova、András György Németh、Charlotte Desczyk、Tímea Imre、Dávid Bajusz、Richard Moriggl、Franz-Josef Meyer-Almes、György M. Keserü

  DOI：10.1021/acs.jmedchem.3c01779

  日期：2024.1.11
• PROKINETICIN 1 RECEPTOR ANTAGONISTS
  申请人：Janssen Pharmaceutica N.V.

  公开号：EP1973886B1

  公开（公告）日：2013-02-27
• NOVEL LXR MODULATORS WITH BICYCLIC CORE MOIETY
  申请人：Phenex-FXR GmbH

  公开号：US20210147398A1

  公开（公告）日：2021-05-20

  The present invention relates to bicyclic compounds (e.g. indoles) containing a sulfonyl moiety, which bind to the liver X receptor (LXRα and/or LXKβ) and act preferably as inverse agonists of LXR.
• US7297705B2
  申请人：——

  公开号：US7297705B2

  公开（公告）日：2007-11-20
• [EN] SOMATOSTATIN MODULATORS AND USES THEREOF<br/>[FR] MODULATEURS DE LA SOMATOSTATINE ET LEURS UTILISATIONS
  申请人：CRINETICS PHARMACEUTICALS INC

  公开号：WO2018013676A1

  公开（公告）日：2018-01-18

  Described herein are compounds that are somatostatin modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders that would benefit from modulation of somatostatin activity.