(E)-1-iodo-4-(tert-butyldimethylsiloxy)-5,5-trimethylene-1-octene | 212311-25-6

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: (E)-1-iodo-4-(tert-butyldimethylsiloxy)-5,5-trimethylene-1-octene
• 英文别名: tert-butyl-[4-iodo-1-(propylcyclobutyl)but-3-enyloxy]dimethylsilane；tert-butyl-[(E)4-iodo-1-(1-propylcyclobutyl)but-3-enyloxy]dimethylsilane；tert-butyl-[(E)-4-iodo-1-(1-propylcyclobutyl)but-3-enoxy]-dimethylsilane
• CAS: 212311-25-6
• 化学式: C₁₇H₃₃IOSi
• 分子量: 408.438
• InChiKey: JLMWXJKOCRNXGG-RIYZIHGNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.69
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (E)-1-iodo-4-(tert-butyldimethylsiloxy)-5,5-trimethylene-1-octene 在 三甲基氯硅烷 、 氢氟酸 、 叔丁基锂 、 lithium,azanidylidenemethylidenecopper,2H-thiophen-2-ide 作用下， 以 四氢呋喃 、 乙醚 、 乙腈 、 正戊烷 为溶剂， 反应 6.5h， 生成
  参考文献：
  名称：

  Development of a highly selective EP2-receptor agonist. Part 1: identification of 16-hydroxy-17,17-trimethylene PGE2 derivatives

  摘要：

  Design and synthesis of an EP2-receptor selective agonist began with the chemical modification of alpha- and omega-chains of butaprost 1a, which exhibits an affinity for the IP-receptor. Two series of prostaglandin (PG) analogues with a 16-hydroxy-17,17-trimethylene moiety as an omega-chain were identified. Among those tested, 4a,b,e,f,h and 6a,b,e,f,h were found to be highly selective EP2-receptor agonists. Structure activity relationships are discussed. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(01)00369-8
• 作为产物：
  描述：

  环丁基甲酸 在 2,6-二甲基吡啶 、 lithium aluminium tetrahydride 、 Schwartz's reagent 、 草酰氯 、 magnesium 、 二甲基亚砜 、 三乙胺 、 mercury dichloride 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 乙醚 、 二氯甲烷 为溶剂， 反应 19.01h， 生成 (E)-1-iodo-4-(tert-butyldimethylsiloxy)-5,5-trimethylene-1-octene
  参考文献：
  名称：

  Development of a highly selective EP2-receptor agonist. Part 1: identification of 16-hydroxy-17,17-trimethylene PGE2 derivatives

  摘要：

  Design and synthesis of an EP2-receptor selective agonist began with the chemical modification of alpha- and omega-chains of butaprost 1a, which exhibits an affinity for the IP-receptor. Two series of prostaglandin (PG) analogues with a 16-hydroxy-17,17-trimethylene moiety as an omega-chain were identified. Among those tested, 4a,b,e,f,h and 6a,b,e,f,h were found to be highly selective EP2-receptor agonists. Structure activity relationships are discussed. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(01)00369-8

文献信息

• 3,7 or 3 and 7 thia or oxa prostanoic acid derivatives as agents for lowering intraocular pressure
  申请人：Allergan Sales, Inc.

  公开号：US06410591B1

  公开（公告）日：2002-06-25

  The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma a therapeutically effective amount of a 3, 7 or 3 and 7 thia or oxa prostanoic acid derivative.

  本发明提供了一种治疗眼压升高或青光眼的方法，包括向患有眼压升高或青光眼的动物施用治疗有效量的3、7或3和7硫或氧代前列腺酸衍生物。
• Novel Sulfonamides
  申请人：Burk M. Robert

  公开号：US20070043090A1

  公开（公告）日：2007-02-22

  The present invention provides wherein R 1 is selected from the group consisting of C 1 -C 10 alkoxy, OH and NR 4 R 5 ; R 2 is selected from the group consisting of C 1 -C 10 alkyl and (CH 2 ) n OH; R 3 is selected from the group consisting of C 1 -C 10 alkyl, heteroaryl, e.g. thienyl, furanyl and pyridyl, phenyl, mono, -di-, tri-substituted phenyl and heteroaryl; R 4 and R 5 are independently selected from the group consisting of H, C 1 -C 10 alkyl, C 1 -C 10 alkyl hydroxyl; m is 0 or an integer from 1 to 3 and n is an integer of from 1 to 4. These compounds are useful in lowering intraocular pressure and/or treating glaucoma or providing neuroprotection to the eye of a human patient.

  本发明提供其中R1选自C1-C10烷氧基，OH和NR4R5所组成的群；R2选自C1-C10烷基和(CH2)nOH所组成的群；R3选自C1-C10烷基，杂环芳基，如噻吩基，呋喃基和吡啶基，苯基，单取代，双取代，三取代苯基和杂环芳基；R4和R5分别选自H，C1-C10烷基，C1-C10烷基羟基；m为0或从1到3的整数，n为从1到4的整数。这些化合物在降低眼内压和/或治疗青光眼或为人类患者的眼睛提供神经保护方面具有用处。