3-环丙基-4-甲基吡啶 | 1245643-68-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 3-环丙基-4-甲基吡啶
• 英文名称: 3-cyclopropyl-4-methylpyridine
• CAS: 1245643-68-8
• 化学式: C₉H₁₁N
• 分子量: 133.193
• InChiKey: QBBNWNGOSDSUCO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4-甲基-3-溴吡啶 、 环丙基硼酸 在 potassium phosphate tribasic heptahydrate 、 C₄₅H₅₃ClFeNO₂PPd 作用下， 以 水 、 甲苯 为溶剂， 反应 8.0h， 以52%的产率得到3-环丙基-4-甲基吡啶
  参考文献：
  名称：

  Facile synthesis of aryl(het)cyclopropane catalyzed by palladacycle

  摘要：

  Sphos (2-dicyclohexylphosphino-2',6'-dimethoxy-1,1'-biphenyl) adduct of cyclopalladated ferrocenylimine (Ile) exhibited highly catalytic activity for the Suzuki cross-coupling reaction of cyclopropylboronic acid with aryl(het) halides with 1 mol % catalyst loading. This process was applied to both of aryl and heteroaryl halides (Br and Cl), and made the various arylcyclopropane and heteroarylcyclopropane to be easily synthesized. A variety of substituents on the aryl halides, such as alkyl, acetyl, benzoyl, ether, formyl, carboxylate, methoxy, nitro and cyano were tolerated. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.11.024

文献信息

• [EN] NOVEL IMIDAZOLES USEFUL AS PLANT FUNGICIDES<br/>[FR] NOUVEAUX IMIDAZOLES UTILES EN TANT QUE FONGICIDES POUR PLANTE
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2012084678A1

  公开（公告）日：2012-06-28

  Compounds of the general formula (I) wherein the substituents are as defined in claim 1, are useful as fungicides.

  通式(I)中取代基如权利要求书中定义的化合物，可用作杀菌剂。
• BENZIMIDAZOLONE DERIVATIVES AS BROMODOMAIN INHIBITORS
  申请人：Gilead Sciences, Inc.

  公开号：US20140296246A1

  公开（公告）日：2014-10-02

  This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R 1a , R 1b , R 2a , R 2b , R 3 , and X are described herein.

  本申请涉及一种化合物，它可以作为溴域含有蛋白质（包括溴域含有蛋白质4（BRD4））的抑制剂或调节剂，以及包含这种化合物的组合物和配方，以及使用和制备这种化合物的方法。该化合物包括公式（I）中所描述的R1a，R1b，R2a，R2b，R3和X的化合物。
• KRAS G12C inhibitors and methods of using the same
  申请人：AMGEN INC.

  公开号：US11285135B2

  公开（公告）日：2022-03-29

  Provided herein are methods of treating cancer with KRAS G12C inhibitors of Formula I and compositions of the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

  本文提供了用式 I 的 KRAS G12C 抑制剂及其组合物治疗癌症的方法。这些抑制剂可用于治疗多种疾病，包括胰腺癌、结直肠癌和肺癌。
• KRAS G12C INHIBITORS AND METHODS OF USING THE SAME
  申请人：AMGEN INC.

  公开号：US20200069657A1

  公开（公告）日：2020-03-05

  Provided herein are methods of treating cancer with KRAS G12C inhibitors and compositions of the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.