| 1404439-45-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• CAS: 1404439-45-7
• 化学式: C₁₄H₁₃NO₂S
• 分子量: 264.289
• InChiKey: HVCKVBQOKOFBFH-VIQYUKPQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  18.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  46.5
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  对甲苯磺酰叠氮 、 在 bis[dichloro(pentamethylcyclopentadienyl)iridium(III)] 、 双三氟甲烷磺酰亚胺银盐 、 盐酸 作用下， 以 1,2-二氯乙烷 、 水 为溶剂， 反应 15.0h， 以8.4 mg的产率得到
  参考文献：
  名称：

  Iridium-Catalyzed Direct ortho-C–H Amidation of Benzaldehydes through N-Sulfonyl Imines as Mask

  摘要：

  Ir-catalyzed direct C-H sulfamiclation of benzaldehydes has been achieved. A series of ortho-amided benzaldehydes were obtained in up to 95% yields for 21 examples with excellent regioselectivity and broad functional group tolerance. This transformation could proceed smoothly with low catalyst loading under external-oxidant-, acid-, or base-free conditions. Molecular nitrogen was released as the sole byproduct, providing an environmentally benign sulfamidation process.

  DOI：

  10.1021/acs.orglett.6b02406

文献信息

• Ruthenium- and Sulfonamide-Catalyzed Cyclization between <i>N</i>-Sulfonyl Imines and Alkynes
  作者：Peng Zhao、Fen Wang、Keli Han、Xingwei Li

  DOI：10.1021/ol302594w

  日期：2012.11.2

  Ruthenium(II)-catalyzed redox-neutral annulative coupling of N-sulfonyl imines with alkynes has been achieved for the synthesis of indenamines, where a sulfonamide cocatalyst is necessary.
• Rh(III)-Catalyzed Olefination of <i>N</i>-Sulfonyl Imines: Synthesis of <i>Ortho</i>-Olefinated Benzaldehydes
  作者：Tao Zhang、Lamei Wu、Xingwei Li

  DOI：10.1021/ol403178a

  日期：2013.12.20

  Rh(III)-catalyzed olefination of N-sulfonyl imines using acrylates and styrenes has been achieved for the synthesis of ortho-olefinated benaldehydes. This reaction proceeds via a chelation assisted C-H olefination/in situ hydrolysis process.