(5R)-5-[tert-butyl(dimethyl)silyl]oxy-7-[(4-methoxyphenyl)methoxy]-1-[(2S,3S)-2-methyl-1,4-dioxaspiro[4.5]decan-3-yl]hept-3-yn-2-one | 1158818-55-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (5R)-5-[tert-butyl(dimethyl)silyl]oxy-7-[(4-methoxyphenyl)methoxy]-1-[(2S,3S)-2-methyl-1,4-dioxaspiro[4.5]decan-3-yl]hept-3-yn-2-one
• CAS: 1158818-55-3
• 化学式: C₃₀H₄₆O₆Si
• 分子量: 530.777
• InChiKey: ALQLWBQLQDKANI-RNCAPKPVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.42
• 重原子数：
  37
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  63.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (5R)-5-[tert-butyl(dimethyl)silyl]oxy-7-[(4-methoxyphenyl)methoxy]-1-[(2S,3S)-2-methyl-1,4-dioxaspiro[4.5]decan-3-yl]hept-3-yn-2-one 在 (S,S)-Noyori catalist 作用下， 以 异丙醇 为溶剂， 以86%的产率得到(2S,5R)-5-[tert-butyl(dimethyl)silyl]oxy-7-[(4-methoxyphenyl)methoxy]-1-[(2S,3S)-2-methyl-1,4-dioxaspiro[4.5]decan-3-yl]hept-3-yn-2-ol
  参考文献：
  名称：

  Stereoselective total synthesis of synparvolide B and epi-synparvolide A

  摘要：

  Stereoselective total synthesis of synparvolide B and epi-synparvolide A has been achieved following a convergent approach. Noyori asymmetric Transfer Hydrogenation of ketone and Wadsworth-Emmons olefination reaction are the key steps involved. (C) 2009 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2009.03.006
• 作为产物：
  描述：

  (2S,3R)-3-(iodomethyl)-2-methyl-1,4-dioxaspiro[4.5]decane 、 (4R)-4-[tert-butyl(dimethyl)silyl]oxy-N-methoxy-6-[(4-methoxyphenyl)methoxy]-N-methylhex-2-ynamide 在 叔丁基锂 作用下， 以 乙醚 为溶剂， 反应 0.5h， 以33%的产率得到(5R)-5-[tert-butyl(dimethyl)silyl]oxy-7-[(4-methoxyphenyl)methoxy]-1-[(2S,3S)-2-methyl-1,4-dioxaspiro[4.5]decan-3-yl]hept-3-yn-2-one
  参考文献：
  名称：

  Stereoselective total synthesis of synparvolide B and epi-synparvolide A

  摘要：

  Stereoselective total synthesis of synparvolide B and epi-synparvolide A has been achieved following a convergent approach. Noyori asymmetric Transfer Hydrogenation of ketone and Wadsworth-Emmons olefination reaction are the key steps involved. (C) 2009 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2009.03.006