(4-(methoxymethoxy)-2,3-dihydrobenzofuran-6-yl)-methanol | 1219924-29-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 香豆素
• 英文名称: (4-(methoxymethoxy)-2,3-dihydrobenzofuran-6-yl)-methanol
• 英文别名: (4-(Methoxymethoxy)-2,3-dihydrobenzofuran-6-yl)methanol；[4-(methoxymethoxy)-2,3-dihydro-1-benzofuran-6-yl]methanol
• CAS: 1219924-29-4
• 化学式: C₁₁H₁₄O₄
• 分子量: 210.23
• InChiKey: NJPZJWHPASQJFJ-UHFFFAOYSA-N

物化性质

• 沸点：
  380.2±42.0 °C(predicted)
• 密度：
  1.234±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  15.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  47.92
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  (4-(methoxymethoxy)-2,3-dihydrobenzofuran-6-yl)-methanol 在 三甲基氯硅烷 、 三丁基膦 、 偶氮二甲酰二哌啶 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 36.5h， 生成 5-((3,4-difluorophenoxy)methyl)-2,3-dihydrobenzofuran-4-ol
  参考文献：
  名称：

  [EN] TEAD INHIBITORS
  [FR] INHIBITEURS DE TEAD

  摘要：

  The present invention relates to a compound of formula (I) wherein A, Z, L, R1, R2, R3, R4, R5and R33are as defined in claim 1, or a pharmaceutically acceptable salt thereof. The compounds of formula (I) possess utility as inhibitors of TEAD. The compounds are useful as medicaments in the treatment of diseases or conditions wherein inhibition of TEAD is desired, such as cancer and chronic pain.

  公开号：

  WO2022219246A1
• 作为产物：
  描述：

  methyl 4-hydroxy-2,3-dihydrobenzofuran-6-carboxylate 在 lithium aluminium tetrahydride 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 36.0h， 生成 (4-(methoxymethoxy)-2,3-dihydrobenzofuran-6-yl)-methanol
  参考文献：
  名称：

  [EN] TEAD INHIBITORS
  [FR] INHIBITEURS DE TEAD

  摘要：

  The present invention relates to a compound of formula (I) wherein A, Z, L, R1, R2, R3, R4, R5and R33are as defined in claim 1, or a pharmaceutically acceptable salt thereof. The compounds of formula (I) possess utility as inhibitors of TEAD. The compounds are useful as medicaments in the treatment of diseases or conditions wherein inhibition of TEAD is desired, such as cancer and chronic pain.

  公开号：

  WO2022219246A1

文献信息

• Structural analogues of schweinfurthin F: Probing the steric, electronic, and hydrophobic properties of the D-ring substructure
  作者：Natalie C. Ulrich、John G. Kodet、Nolan R. Mente、Craig H. Kuder、John A. Beutler、Raymond J. Hohl、David F. Wiemer

  DOI：10.1016/j.bmc.2009.12.063

  日期：2010.2

  The natural tetracyclic schweinfurthins are potent and selective inhibitors of cell growth in the National Cancer Institute's 60-cell line screen. An interest in determination of their cellular or molecular target has inspired our efforts to prepare both the natural products and analogues. In this paper, chemical synthesis of analogues modified in different olefinic positions, and preliminary results from studies of their biological activity, are reported. (C) 2010 Elsevier Ltd. All rights reserved.