1-Methoxy-2-(2-methoxypropyl)benzene | 65725-88-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Methoxy-2-(2-methoxypropyl)benzene
• CAS: 65725-88-4
• 化学式: C₁₁H₁₆O₂
• 分子量: 180.247
• InChiKey: ZHRBALHTSJKPEA-UHFFFAOYSA-N

物化性质

• 沸点：
  226.6±15.0 °C(Predicted)
• 密度：
  0.969±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  甲醇 、 2-(1-propenyl)anisole 在 2-苯基丙二腈 、 9-mesityl-10-methylacridinium chloride 、 1,3-Bis(2,6-difluorophenyl)thiourea 作用下， 以 1,2-二氯乙烷 为溶剂， 以61 %的产率得到1-Methoxy-2-(2-methoxypropyl)benzene
  参考文献：
  名称：

  Unlocking Photocatalytic Activity of Acridinium Salts by Anion‐Binding Co‐Catalysis

  摘要：

  The in situ generation of active photoredox organic catalysts upon anion‐binding co‐catalysis by making use of the ionic nature of common photosensitizers is reported. Hence, the merge of anion‐binding and photocatalysis permitted the modulation of the photocatalytic activity of simple acridinium halide salts, building an effective anion‐binding – photoredox ion pair complex able to promote a variety of visible light driven transformations, such as anti‐Markovnikov addition to olefins, Diels‐Alder and the desilylative C−C bond forming reactions. Anion‐binding studies, together with steady‐state and time‐resolved spectroscopy analysis, supported the postulated ion pair formation between the thiourea hydrogen‐bond donor organocatalyst and the acridinium salt, which proved essential for unlocking the photocatalytic activity of the photosensitizer.

  DOI：

  10.1002/chem.202400541

文献信息

• Hydroalkoxylation of Unactivated Olefins with Carbon Radicals and Carbocation Species as Key Intermediates
  作者：Hiroki Shigehisa、Tatsuya Aoki、Sumiko Yamaguchi、Nao Shimizu、Kou Hiroya

  DOI：10.1021/ja405219f

  日期：2013.7.17

  A unique Markovnikov hydroalkoxylation of unactivated olefins with a cobalt complex, silane, and N-fluoropyridinium salt is reported. Further optimization of reaction conditions yielded high functional group tolerance and versatility of alcoholic solvent employed, including methanol, i-propanol, and t-butanol. Use of trifluorotoluene as a solvent made the use of alcohol in stoichiometric amount possible. Mechanistic insight into this novel catalytic system is also discussed. Experimental results suggest that catalysis involves both carbon radical and carbocation intermediates.
• MASTRAL A. M.; BARLUENGA J., AFINIDAD, 1979, 36, NO 363, 401-404
  作者：MASTRAL A. M.、 BARLUENGA J.

  DOI：——

  日期：——