[Pt(cyclobutylamine)(NH3)(D2O)2](2+) | 1161927-46-3

• 分子结构分类: 有机化合物 - 碳氢化合物 - 多环烃
• 英文名称: [Pt(cyclobutylamine)(NH3)(D2O)2](2+)
• 英文别名: [Pt(cba)(NH3)(D2O)2](2+)
• CAS: 1161927-46-3
• 化学式: C₄H₁₆N₂O₂Pt
• 分子量: 323.231
• InChiKey: RZFRXBLZIXUYDR-JBISRTOLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  鸟苷 、 [Pt(cyclobutylamine)(NH3)(D2O)2](2+) 以 重水 为溶剂， 生成 cis-Pt(cyclobutylamine)2(guanosine)2(2+) 、 cis-Pt(cyclobutylamine)(NH3)(guanosine)2(2+)
  参考文献：
  名称：

  Multinuclear magnetic resonance studies of the reactions of the antitumor complexes cis-Pt(L)2X2 and cis-Pt(NH3)(L)X2 (L=cyclobutylamine and cyclopentylamine) with guanosine and other bases and crystal structures of Pt(cyclopentylamine)2I2

  摘要：

  The crystal structures of two Pt(cyclopentylamine) I-2(2) compounds were determined by X-ray diffraction methods. Both crystals contain disordered cyclopentylamine ligands. Crystal I contains two independent trans-Pt(cyclopentylamine)(2)I-2 molecules and all the C atoms are disordered on two positions. The second crystal (II) is most interesting since it contains both cis- and trans-Pt(cyclopentylamine)(2)I-2 isomers in the same unit cell. It was prepared from the recrystallization of the cis isomer in acetone. The C atoms of the trans molecule in crystal II are disordered on two positions, while only one position was determined in the cis molecule, although some of the C thermal factors are quite high. The reactions of cis-Pt(amine)(2)X-2 and cis-Pt(NH3)(amine) X-2 (amine = cyclobutylamine and cyclopentylamine) with guanosine in water were studied in different Pt: guanosine proportions by multinuclear (H-1, Pt-195 and N-15) magnetic resonance spectroscopy. The presence of several species in solution was observed. For the mixed-cyclobutylamine compound, N-15 NMR has shown that some of the NH3 ligands have been displaced from the coordination sphere in the presence of an excess of guanosine. The reactions of the two mixed-ligand complexes cis-Pt(NH3)(amine) Cl-2 with 9-methylguanine, inosine and 9-methylhypoxanthine were also studied in water and the results are discussed. (C) 2008 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2008.10.026
• 作为产物：
  描述：

  cis-[PtNH3(cyclobutylamino)I2] 、 重水 、 silver nitrate 以 重水 为溶剂， 生成 cis-[Pt(cyclobutylamine)2(D2O)2](2+) 、 [Pt(cyclobutylamine)(NH3)(NO3)(D2O)](1+) 、 [Pt(cyclobutylamine)(NH3)(D2O)2](2+) 、 cis-[Pt(cyclobutylamine)2(NO3)(D2O)](1+)
  参考文献：
  名称：

  水解和水合抗肿瘤复合物顺-Pt（环丁胺）2X2和顺-Pt（NH3）（环丁胺）X2的水解和水合物种的多核磁共振研究以及混合胺Pt（II）化合物的抗肿瘤试验

  摘要：

  摘要用多核（195 Pt，15 N和1 H）研究了由顺式Pt（cba）2 I 2和顺式Pt（NH 3）（cba）I 2（cba =环丁胺）络合物形成的水合水解物种。 ）磁共振波谱学。用AgNO 3除去碘配体。在酸性介质中，水性产物由diadia和aqua-nitroato阳离子组成，尽管在几个小时后会形成一些单羟基桥接的二聚体，尤其是对于混合的配体化合物。在碱性介质中，主要物质是二羟基化合物。在中性pD下，溶液中存在几种物质，尤其是在混合胺系统中，该系统还包含少量对称的顺式Pt（cba）2络合物。遇到困难的原因是与cis-Pt（NH 3）2系统相反，一些寡聚物种不溶，可能是由于cba的亲脂性比NH 3高。单羟基桥连的二聚体大量形成，并且通过15 N NMR光谱确定混合胺物种的立体化学。对于后一种系统，数小时后，在中性pD下，环状二氢桥联二聚体是主要物质。延长的时间后，大多数低聚物沉淀，将更

  DOI：

  10.1016/j.ica.2008.09.004