4,4-Difluoropyrrolidine-2-carbonitrile hydrochloride | 2225136-14-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 4,4-Difluoropyrrolidine-2-carbonitrile hydrochloride
• 英文别名: 4,4-difluoropyrrolidine-2-carbonitrile;hydrochloride
• CAS: 2225136-14-9
• 化学式: C5H7ClF2N2
• 分子量: 168.57
• InChiKey: BOGMTOHWIVLVJE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.93
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  35.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• INHIBITORS OF FIBROBLAST ACTIVATION PROTEIN
  申请人：Praxis Biotech LLC

  公开号：US20190185451A1

  公开（公告）日：2019-06-20

  Compounds and compositions for modulating fibroblast activation protein (FAP) are described. The compounds and compositions may find use as therapeutic agents for the treatment of diseases, including hyperproliferative diseases.

  描述了用于调节成纤维细胞活化蛋白（FAP）的化合物和组合物。这些化合物和组合物可能被用作治疗疾病的治疗剂，包括高增殖性疾病。
• [EN] INHIBITORS OF FIBROBLAST ACTIVATION PROTEIN<br/>[FR] INHIBITEURS DE LA PROTÉINE D'ACTIVATION DES FIBROBLASTES
  申请人：PRAXIS BIOTECH LLC

  公开号：WO2019118932A1

  公开（公告）日：2019-06-20

  Compounds and compositions for modulating fibroblast activation protein (FAP) are described. The compounds and compositions may find use as therapeutic agents for the treatment of diseases, including hyperproliferative diseases.
• [EN] INHIBITORS OF FIBROBLAST ACTIVATION PROTEIN<br/>[FR] INHIBITEURS DE PROTÉINE D'ACTIVATION DES FIBROBLASTES
  申请人：PRAXIS BIOTECH LLC

  公开号：WO2020132661A2

  公开（公告）日：2020-06-25

  Compounds and compositions for modulating fibroblast activation protein (FAP) are described. The compounds and compositions may find use as therapeutic agents for the treatment of diseases, including hyperproliferative diseases.