10-[3-(3-piperidin-1-yl-propoxy)-phenyl]-6,7,8,9-tetrahydro-5H-1,4,10a-triaza-cyclohepta[f]indene | 873014-89-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 10-[3-(3-piperidin-1-yl-propoxy)-phenyl]-6,7,8,9-tetrahydro-5H-1,4,10a-triaza-cyclohepta[f]indene
• 英文别名: 8-[3-(3-Piperidin-1-ylpropoxy)phenyl]-2,6,7-triazatricyclo[7.5.0.03,7]tetradeca-1,3,5,8-tetraene
• CAS: 873014-89-2
• 化学式: C₂₅H₃₂N₄O
• 分子量: 404.555
• InChiKey: JWIQGCRZKNUKMS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  42.7
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Non-imidazole tertiary amines as histamine 3 receptor inhibitors for the treatment of cognitive and sleep disorders, obesity and other CNS disorders
  申请人：Bennani L. Youssef

  公开号：US20060009451A1

  公开（公告）日：2006-01-12

  This invention relates to compounds having pharmacological activity, to compositions containing these compounds, and to a method of treatment employing the compounds and compositions. More particularly, this invention concerns certain non-imidazole tertiary amine derivatives and their salts and solvates. These compounds have H 3 histamine receptor antagonist activity. This invention also relates to pharmaceutical compositions containing these compounds and to a method of treating disorders in which histamine H 3 receptor blockade is beneficial.

  本发明涉及具有药理活性的化合物，含有这些化合物的组合物，以及使用这些化合物和组合物的治疗方法。更具体地说，这项发明涉及某些非咪唑三级胺衍生物及其盐和溶剂化合物。这些化合物具有H3组胺受体拮抗活性。本发明还涉及含有这些化合物的药物组合物，以及一种治疗在其中组胺H3受体阻滞有益的疾病的方法。
• NON-IMIDAZOLE TERTIARY AMINES AS HISTAMINE 3 RECEPTOR INHIBITORS FOR THE TREATMENT OF COGNITIVE AND SLEEP DISORDERS, OBESITY AND OTHER CNS DISORDERS
  申请人：Athersys, Inc.

  公开号：EP1773345B1

  公开（公告）日：2013-12-11
• US7319103B2
  申请人：——

  公开号：US7319103B2

  公开（公告）日：2008-01-15