1-[(E)-1-(benzenesulfonyl)but-2-enyl]-4-chlorobenzene | 1198425-46-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[(E)-1-(benzenesulfonyl)but-2-enyl]-4-chlorobenzene
• CAS: 1198425-46-5
• 化学式: C₁₆H₁₅ClO₂S
• 分子量: 306.813
• InChiKey: TVRHZUQGVWLTKO-QHHAFSJGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  42.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  苯亚磺酰氯 、 4-(4-chlorophenyl)-3-buten-2-ol 以 氯仿 为溶剂， 反应 4.0h， 生成 1-[(E)-3-(benzenesulfonyl)but-1-enyl]-4-chlorobenzene 、 1-[(E)-1-(benzenesulfonyl)but-2-enyl]-4-chlorobenzene
  参考文献：
  名称：

  An Expeditious Entry to Benzylic and Allylic Sulfones through Byproduct-Catalyzed Reaction of Alcohols with Sulfinyl Chlorides

  摘要：

  In the absence of external catalysts and additives, a broad range of benzylic and allylic alcohols react with various sulfinyl chlorides to afford structurally diversified benzylic and allylic sulfones in moderate to excellent yields, and importantly, a catalysis with byproduct HCl is involved in this new protocol for sulfone synthesis.

  DOI：

  10.1021/jo901974h

文献信息

• An Expeditious Entry to Benzylic and Allylic Sulfones through Byproduct-Catalyzed Reaction of Alcohols with Sulfinyl Chlorides
  作者：Hai-Hua Li、De-Jun Dong、Yin-Huan Jin、Shi-Kai Tian

  DOI：10.1021/jo901974h

  日期：2009.12.18

  In the absence of external catalysts and additives, a broad range of benzylic and allylic alcohols react with various sulfinyl chlorides to afford structurally diversified benzylic and allylic sulfones in moderate to excellent yields, and importantly, a catalysis with byproduct HCl is involved in this new protocol for sulfone synthesis.