(S)-2-{[(S)-1,2-Bis-(3,4-dimethoxy-phenyl)-ethyl]-methyl-amino}-3-methyl-butan-1-ol | 210533-48-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-2-{[(S)-1,2-Bis-(3,4-dimethoxy-phenyl)-ethyl]-methyl-amino}-3-methyl-butan-1-ol
• CAS: 210533-48-5
• 化学式: C₂₄H₃₅NO₅
• 分子量: 417.546
• InChiKey: UXBKISBHCYFSJJ-VQTJNVASSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.95
• 重原子数：
  30.0
• 可旋转键数：
  11.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  60.39
• 氢给体数：
  1.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  (S)-2-{[(S)-1,2-Bis-(3,4-dimethoxy-phenyl)-ethyl]-methyl-amino}-3-methyl-butan-1-ol 在 草酰氯 、 二乙基异丙基胺 、 二甲基亚砜 作用下， 生成
  参考文献：
  名称：

  Stereochemical studies on the synthesis of 1,2,3,4-tetrahydroisoquinolin-4-ols

  摘要：

  The stereoselectivity of the acid catalyzed promoted cyclization of adequately substituted alpha-aminoaldehydes to afford a series of tetrahydroisoquinolin-4-ols is studied. The results illustrate the effect of the substituents at C-l and/or C-3 in the target heterocycle. The required precursors 5 and 10 were synthesized from the enantiomerically pure (-)-imines 1 by two different routes, and reacted with cone. HCl. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(98)00164-5
• 作为产物：
  描述：

  聚合甲醛 、 (2S)-2-[[(1S)-1,2-bis(3,4-dimethoxyphenyl)ethyl]amino]-3-methylbutan-1-ol 在 sodium cyanoborohydride 作用下， 以 水 、 乙腈 为溶剂， 反应 15.0h， 以80%的产率得到(S)-2-{[(S)-1,2-Bis-(3,4-dimethoxy-phenyl)-ethyl]-methyl-amino}-3-methyl-butan-1-ol
  参考文献：
  名称：

  Stereochemical studies on the synthesis of 1,2,3,4-tetrahydroisoquinolin-4-ols

  摘要：

  The stereoselectivity of the acid catalyzed promoted cyclization of adequately substituted alpha-aminoaldehydes to afford a series of tetrahydroisoquinolin-4-ols is studied. The results illustrate the effect of the substituents at C-l and/or C-3 in the target heterocycle. The required precursors 5 and 10 were synthesized from the enantiomerically pure (-)-imines 1 by two different routes, and reacted with cone. HCl. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(98)00164-5