2'-(3'''-methyl-butoxy)-3',5'-dihydroxy-p-terphenyl | 1034017-38-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2'-(3'''-methyl-butoxy)-3',5'-dihydroxy-p-terphenyl
• 英文别名: 4-(3-Methylbutoxy)-2,5-diphenylbenzene-1,3-diol
• CAS: 1034017-38-3
• 化学式: C₂₃H₂₄O₃
• 分子量: 348.442
• InChiKey: UVIQQIGRSSAFBZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3',5'-bis(benzyloxy)-2'-(isopentyloxy)-1,1':4',1''-terphenyl 在 palladium on activated charcoal 氢气 作用下， 以 乙酸乙酯 为溶剂， 20.0 ℃ 、101.33 kPa 条件下， 反应 24.0h， 生成 2'-(3'''-methyl-butoxy)-3',5'-dihydroxy-p-terphenyl
  参考文献：
  名称：

  Active core structure of terfestatin A, a new specific inhibitor of auxin signaling

  摘要：

  The auxins, plant hormones, regulate many aspects of the growth and development of plants. Terfestatin A (TrfA), a novel auxin signaling inhibitor, was identified in a screen of Streptomyces sp. F40 extracts for inhibition of the expression of an auxin-inducible gene. However, the mode of action of TrfA has not been elucidated. To identify the active core structure, 25 derivatives of TrfA were synthesized and their inhibitory activities against auxin-inducible gene expression were evaluated. The structure activity relationships revealed the essential active core structure of TrfA, 3-butoxy-4-methylbiphenyl-2,6-diol, which will lead to the design of biotin-tagged active TrfA. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.02.085

文献信息

• Active core structure of terfestatin A, a new specific inhibitor of auxin signaling
  作者：Ken-ichiro Hayashi、Atsushi Yamazoe、Yuki Ishibashi、Naoyuki Kusaka、Yutaka Oono、Hiroshi Nozaki

  DOI：10.1016/j.bmc.2008.02.085

  日期：2008.5

  The auxins, plant hormones, regulate many aspects of the growth and development of plants. Terfestatin A (TrfA), a novel auxin signaling inhibitor, was identified in a screen of Streptomyces sp. F40 extracts for inhibition of the expression of an auxin-inducible gene. However, the mode of action of TrfA has not been elucidated. To identify the active core structure, 25 derivatives of TrfA were synthesized and their inhibitory activities against auxin-inducible gene expression were evaluated. The structure activity relationships revealed the essential active core structure of TrfA, 3-butoxy-4-methylbiphenyl-2,6-diol, which will lead to the design of biotin-tagged active TrfA. (C) 2008 Elsevier Ltd. All rights reserved.