2-(2,2-difluoroethoxy)isoindole-1,3-dione | 146536-57-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-(2,2-difluoroethoxy)isoindole-1,3-dione
• 英文别名: 2-(2,2-Difluoro-ethoxy)-isoindole-1,3-dione
• CAS: 146536-57-4
• 化学式: C₁₀H₇F₂NO₃
• 分子量: 227.167
• InChiKey: ODDSODOLAJUPAX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-(2,2-difluoroethoxy)isoindole-1,3-dione 在 一水合肼 作用下， 以 二氯甲烷 为溶剂， 以85 %的产率得到O-（2,2-二氟乙基）羟胺盐酸盐
  参考文献：
  名称：

  [EN] GONADOTROPIN-RELEASING HORMONE ANTAGONIST, AND PREPARATION METHOD THEREFOR AND USE THEREOF
  [FR] ANTAGONISTE DE L'HORMONE DE LIBÉRATION DE LA GONADOTROPINE, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION
  [ZH] 促性腺素释放激素拮抗剂及其制备方法和应用

  摘要：

  涉及一类促性腺素释放激素拮抗剂，其具有对促性腺激素释放激素的拮抗活性，并且可以用于预防或治疗性激素依赖性疾病，例如良性前列腺肥大、子宫肌瘤、子宫内膜异位、子宫纤维瘤、性早熟、闭经、经前期综合征、痛经等，或其前体药物，或其药学可接受的盐，或其水合物或溶剂化物，和含有其的药物组合物。 (I)

  公开号：

  WO2023072284A1
• 作为产物：
  描述：

  N-羟基邻苯二甲酰亚胺 、 2,2-二氟乙醇 以affording XCVIII in 52% yield的产率得到2-(2,2-difluoroethoxy)isoindole-1,3-dione
  参考文献：
  名称：

  Compounds and compositions for treatment of breathing control disorders or diseases

  摘要：

  本发明涉及化合物和包含它们的组合物，其在治疗需要治疗呼吸控制疾病或障碍的受试者中有用。本发明还包括一种治疗需要治疗呼吸系统疾病或障碍的受试者的方法，包括向受试者施用本发明化合物的治疗有效量。本发明还包括一种预防不稳定或稳定呼吸节律的方法，包括向需要该治疗的受试者施用本发明化合物的治疗有效量。

  公开号：

  US09162992B2

文献信息

• [EN] NOVEL COMPOUNDS AS RESPIRATORY STIMULANTS FOR TREATMENT OF BREATHING CONTROL DISORDERS OR DISEASES<br/>[FR] NOUVEAUX COMPOSÉS COMME STIMULANTS RESPIRATOIRES POUR LE TRAITEMENT DE TROUBLES OU DE MALADIES DE CONTRÔLE DE LA RESPIRATION
  申请人：GALLEON PHARMACEUTICALS INC

  公开号：WO2012074999A1

  公开（公告）日：2012-06-07

  The present invention includes compositions that are useful in the treatment of breathing control diseases or disorders in a subject in need thereof. The present invention also includes a method of treating a respiratory disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a pharmaceutical formulation of the invention, The present invention further includes a method of preventing destabilization or stabilizing breathing rhythm in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a pharmaceutical formulation of the invention.

  本发明涵盖了用于治疗患有呼吸控制疾病或紊乱的受试者的组合物。本发明还包括一种治疗患有呼吸系统疾病或紊乱的受试者的方法，包括向受试者施用本发明的药物配方的治疗有效量。本发明还包括一种预防或稳定患有呼吸节律不稳定的受试者的方法，包括向受试者施用本发明的药物配方的治疗有效量。
• Novel Compounds and Compositions for Treatment of Breathing Control Disorders or Diseases
  申请人：Mannion James C.

  公开号：US20120295911A1

  公开（公告）日：2012-11-22

  The present invention includes compositions that are useful in the treatment of breathing control diseases or disorders in a subject in need thereof. The present invention also includes a method of treating a respiratory disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a pharmaceutical formulation of the invention. The present invention further includes a method of preventing destabilization or stabilizing breathing rhythm in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a pharmaceutical formulation of the invention.

  本发明包括用于治疗需要呼吸控制疾病或障碍的受体的组合物。本发明还包括一种治疗需要呼吸系统疾病或障碍的受体的方法，包括向受体施用本发明的药物制剂的治疗有效量。本发明还包括一种预防或稳定需要呼吸节律的受体的方法，包括向受体施用本发明的药物制剂的治疗有效量。
• Novel Compounds as Respiratory Stimulants for Treatment of Breathing Control Disorders or Diseases
  申请人：Dax Scott L.

  公开号：US20120142647A1

  公开（公告）日：2012-06-07

  The present invention includes compositions that are useful in the treatment of breathing control diseases or disorders in a subject in need thereof. The present invention also includes a method of treating a respiratory disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a pharmaceutical formulation of the invention. The present invention further includes a method of preventing destabilization or stabilizing breathing rhythm in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a pharmaceutical formulation of the invention.

  本发明包括用于治疗呼吸控制疾病或障碍的组合物，适用于需要该治疗的受试者。本发明还包括一种治疗呼吸系统疾病或障碍的方法，包括向受试者投予本发明的药物制剂的治疗有效量。本发明还包括一种预防或稳定受试者呼吸节律不稳定的方法，包括向受试者投予本发明的药物制剂的治疗有效量。
• NOVEL COMPOUNDS AND COMPOSITIONS FOR TREATMENT OF BREATHING CONTROL DISORDERS OR DISEASES
  申请人：GALLEON PHARMACEUTICALS, INC.

  公开号：US20140371224A1

  公开（公告）日：2014-12-18

  The present invention includes compounds, and compositions comprising the same, that are useful in the treatment of breathing control diseases or disorders in a subject in need thereof. The present invention also includes a method of treating a respiratory disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of the invention. The present invention further includes a method of preventing destabilization or stabilizing breathing rhythm in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of the invention.

  本发明包括化合物及其组合物，适用于治疗需要治疗呼吸控制疾病或障碍的患者。本发明还包括一种治疗需要治疗呼吸系统疾病或障碍的患者的方法，包括向患者施用本发明中化合物的治疗有效量。本发明还包括一种预防或稳定需要稳定呼吸节律的患者的方法，包括向患者施用本发明中化合物的治疗有效量。
• NOVEL COMPOUNDS AS RESPIRATORY STIMULANTS FOR TREATMENT OF BREATHING CONTROL DISORDERS OR DISEASES
  申请人：GALLEON PHARMACEUTICALS, INC.

  公开号：US20160256463A1

  公开（公告）日：2016-09-08

  The present invention includes a composition comprising a compound, such as a 2,4,6-triamino-1,3,5-triazine, 2,4,6-triaminopyrimidine, 2,4-diamino-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine or 2,4-diamino-7H-pyrrolo[2,3-d]pyrimidine, that is useful in the treatment of breathing control diseases or disorders in a subject in need thereof. The present invention also includes a method of treating a respiratory disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition of the invention. The present invention further includes a method of preventing destabilizing or stabilizing breathing rhythm in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition of the invention.

  本发明涉及一种组合物，包括化合物，如2,4,6-三氨基-1,3,5-三嗪、2,4,6-三氨基嘧啶、2,4-二氨基-6,7-二氢-5H-吡咯[2,3-d]嘧啶或2,4-二氨基-7H-吡咯[2,3-d]嘧啶，其在治疗需要该类治疗的呼吸控制疾病或障碍的患者中有用。本发明还包括一种治疗需要该类治疗的呼吸系统疾病或障碍的患者的方法，包括向该患者施用本发明的药物组合物的治疗有效量。本发明还包括一种预防需要该类治疗的患者呼吸节律不稳定或稳定的方法，包括向该患者施用本发明的药物组合物的治疗有效量。