N-[6-(morpholin-4-ylmethyl)pyridin-2-yl]-6-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazine-3-carboxamide | 1431642-79-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N-[6-(morpholin-4-ylmethyl)pyridin-2-yl]-6-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazine-3-carboxamide
• CAS: 1431642-79-3
• 化学式: C₂₄H₂₁F₃N₆O₂
• 分子量: 482.465
• InChiKey: QJHMMWQYZXHXTF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  35
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  84.6
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS
  申请人：GlaxoSmithKline LLC

  公开号：EP2768509B1

  公开（公告）日：2017-03-22
• US9957271B2
  申请人：——

  公开号：US9957271B2

  公开（公告）日：2018-05-01
• [EN] SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS<br/>[FR] AZAHÉTÉROCYCLES BICYCLIQUES SUBSTITUÉS ET ANALOGUES COMME MODULATEURS DE LA SIRTUINE
  申请人：SIRTRIS PHARMACEUTICALS INC

  公开号：WO2013059587A1

  公开（公告）日：2013-04-25

  Provided herein are novel substituted bicyclic aza-heterocycle sirtuin- modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin- modulating compound in combination with another therapeutic agent.