4-Hydroxy-5-fluor-pyrimidin-6-carbonsaeure-ethylester | 1840-16-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-Hydroxy-5-fluor-pyrimidin-6-carbonsaeure-ethylester
• 英文别名: ethyl 5-fluoro-6-oxo-1H-pyrimidine-4-carboxylate
• CAS: 1840-16-0
• 化学式: C₇H₇FN₂O₃
• 分子量: 186.143
• InChiKey: FAOQYBVMAYMMCJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  67.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Wnt signaling pathway inhibitors and therapeutic applications thereof
  申请人：Suzhou Yunxuan Yiyao Keji Youxian Gongsi

  公开号：US10450300B2

  公开（公告）日：2019-10-22

  Inhibitors of Wnt signaling pathway with structures of Formula I are disclosed, together with their pharmaceutical salts. Applications of compounds of Formula I in inhibiting or modulating the Wnt signaling pathway are also disclosed. Compounds of Formula I can treat disorders caused by aberrant activation of the Wnt signaling pathway.

  本研究公开了具有式 I 结构的 Wnt 信号通路抑制剂及其药用盐。还公开了式 I 化合物在抑制或调节 Wnt 信号通路中的应用。式 I 的化合物可以治疗 Wnt 信号通路异常激活引起的疾病。
• WNT SIGNALING PATHWAY INHIBITORS AND THERAPEUTIC APPLICATIONS THEREOF
  申请人：Suzhou Yunxuan Yiyao Keji Youxian Gongsi

  公开号：EP3359154B1

  公开（公告）日：2021-05-26
• [EN] WNT SIGNALING PATHWAY INHIBITORS AND THERAPEUTIC APPLICATIONS THEREOF<br/>[FR] INHIBITEURS DE LA VOIE DE SIGNALISATION WNT ET LEURS APPLICATIONS THÉRAPEUTIQUES
  申请人：ZHANG XIAOHU

  公开号：WO2017062688A1

  公开（公告）日：2017-04-13

  Inhibitors of Wnt signaling pathway with structures of Formula I are disclosed, together with their pharmaceutical salts. Applications of compounds of Formula I in inhibiting or modulating the Wnt signaling pathway are also disclosed. Compounds of Formula I can treat disorders caused by aberrant activation of the Wnt signaling pathway.