(1S,2S,3R,5R)-3-(6-aminopurin-9-yl)-6-oxabicyclo[3.1.0]hexan-2-ol | 514206-80-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: (1S,2S,3R,5R)-3-(6-aminopurin-9-yl)-6-oxabicyclo[3.1.0]hexan-2-ol
• CAS: 514206-80-5
• 化学式: C₁₀H₁₁N₅O₂
• 分子量: 233.23
• InChiKey: FIOYQOMNPZZDLA-HXOWADHMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  102
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  9-[(1R,2S,3S,4S)-2,3-dihydroxy-4-(methanesulfonyloxy)cyclopentan-1-yl]-9H-adenine 在 potassium tert-butylate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.5h， 以79%的产率得到(1S,2S,3R,5R)-3-(6-aminopurin-9-yl)-6-oxabicyclo[3.1.0]hexan-2-ol
  参考文献：
  名称：

  Synthesis of 3′,4′-epoxynoraristeromycin analogs for molecular labeling probe of S-adenosyl-l-homocysteine hydrolase

  摘要：

  3',4'-Epoxynoraristeromycin analogs were designed and synthesized. Their affinities with human and Plasmodium falciparum S-adenosyl-L-homo-cysteine hydrolase were investigated. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.05.020

文献信息

• Synthesis of 3′,4′-epoxynoraristeromycin analogs for molecular labeling probe of S-adenosyl-l-homocysteine hydrolase
  作者：Hiroharu Kojima、Atsushi Kozaki、Masafumi Iwata、Takayuki Ando、Yukio Kitade

  DOI：10.1016/j.bmc.2008.05.020

  日期：2008.7.1

  3',4'-Epoxynoraristeromycin analogs were designed and synthesized. Their affinities with human and Plasmodium falciparum S-adenosyl-L-homo-cysteine hydrolase were investigated. (c) 2008 Elsevier Ltd. All rights reserved.