3-aminoethylpyrrolidine | 326409-29-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 3-aminoethylpyrrolidine
• 英文别名: 2-(Pyrrolidin-3-yl)ethanamine；2-pyrrolidin-3-ylethanamine
• CAS: 326409-29-4
• 化学式: C₆H₁₄N₂
• 分子量: 114.191
• InChiKey: BGFISPDIDBIVFH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-aminoethylpyrrolidine 、 在 ethylene dichloride hydrochloride 、 1-羟基苯并三唑 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Fragment-based discovery and optimization of BACE1 inhibitors

  摘要：

  A novel series of 2-aminobenzimidazole inhibitors of BACE1 has been discovered using fragment-based drug discovery (FBDD) techniques. The rapid optimization of these inhibitors using structure-guided medicinal chemistry is discussed. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.06.089

文献信息

• Procedure for the preparation of N-cyclopropyl-4-fluoroanilines
  申请人：CENTRO MARGA PARA LA INVESTIGACION S.A.

  公开号：EP0430847A1

  公开（公告）日：1991-06-05

  Procedure for the preparation of N-cyclopropyl-4-fluoroanilines of formula I. By selective reaction of II with cyclopropylamine, piperazines or pyrrolidines, III is obtained. Its acetylation and reduction yields IV which by de-amination leads to I. R¹ is hydrogen, chlorine or methyl; R², hydrogen, halogen, methyl, a piperazinyl or a pyrroledinyl; R³, hydrogen, halogen, hydroxyl or trifluoromethyl; and R⁴, hydrogen, nitro, hydroxyl or amino. The compounds of formula I are of interest on account of their application to the preparation of quinolone group antibiotics.

  制备式I的N-环丙基-4-氟苯胺的过程。通过将II与环丙基胺、哌嗪或吡咯烷选择性反应，得到III。对其进行乙酰化和还原得到IV，再经去氨基化得到I。其中，R¹为氢、氯或甲基；R²为氢、卤素、甲基、哌嗪基或吡咯烷基；R³为氢、卤素、羟基或三氟甲基；R⁴为氢、硝基、羟基或氨基。式I的化合物因其在喹诺酮类抗生素制备中的应用而备受关注。
• RHODAMINE-BASED COLORING COMPOSITION
  申请人：WAKO PURE CHEMICAL INDUSTRIES, LTD.

  公开号：US20170145216A1

  公开（公告）日：2017-05-25

  A colored resin composition using a conventional rhodamine derivative has not provided heat resistance in a practical range. Therefore, it is an object of the present invention to provide a coloring composition having higher heat resistance as compared with the conventional coloring composition. The present invention relates to a compound represented by the following general formula (1), and a polymer having a monomer unit derived from the compound, and the like. (wherein R 1 to R 4 each independently represent a hydrogen atom, an alkyl group, and the like; R 7 represents a hydrogen atom or a methyl group; R 8 and R 9 each independently represent a hydrogen atom or an alkyl group; Y represents a nitrogen atom or a group represented by the following formula (1-1): A 1 represents an alkylene group which has at least one group selected from —O—, —OCO—, —COO—, —NHCO—, —CONH—, —NHCONH— and an arylene group in the chain, and the like; A 2 represents —NH— or —O—; An − represents an anion containing an aryl group having an electron-withdrawing substituent, and the like; n represents an integer of 0 to 3; R 8 and R 9 may form a cyclic structure of a 5 to 6 membered ring together with —N—(CH 2 ) n —Y— bonding thereto.)

  使用传统的罗丹明衍生物的有色树脂组合物在实际范围内未提供耐热性。因此，本发明的目的是提供一种比传统着色组合物具有更高耐热性的着色组合物。本发明涉及由以下通式（1）所代表的化合物，以及具有源自该化合物的单体单位的聚合物等。（其中R1至R4分别独立地代表氢原子、烷基基团等；R7代表氢原子或甲基基团；R8和R9分别独立地代表氢原子或烷基基团；Y代表氮原子或由以下式（1-1）所代表的基团：A1代表在链中至少具有一种从—O—，—OCO—，—COO—，—NHCO—，—CONH—，—NHCONH—和芳基基团中选择的基团的亚烷基基团等；A2代表—NH—或—O—；An−代表含有具有电子吸引取代基的芳基团的阴离子等；n表示0至3的整数；R8和R9可以与结合其的—N—（CH2）n—Y—共同形成5至6元环的环状结构。）
• Process for preparing quinolone and naphthyridone carboxylic acids
  申请人：Pfizer Products Inc.

  公开号：EP0976749A1

  公开（公告）日：2000-02-02

  Antibacterial quinolone carboxylic acids and naphthyridone carboxylic acids, having an external amino group attached to their 7-substituent are prepared without the use, and subsequent removal, of blocking groups on the external amino group. In a preferred embodiment, the naphthyridone carboxylic acid is the antibiotic trovafloxacin.

  具有外部氨基团附加在它们的7-取代基上的抗菌喹诺酸和萘啶酮羧酸，可以在不使用和随后去除外部氨基团上的阻断基的情况下制备。在首选实施例中，萘啶酮羧酸是抗生素曲沃沙星。
• Pyridonecarboxylic acid derivatives
  申请人：DAIICHI PHARMACEUTICAL CO., LTD.

  公开号：EP0207420A2

  公开（公告）日：1987-01-07

  This invention provides novel pyridonecarboxyic acid derivatives having a quite high antimicrobial activity. The derivatives have the following formula: wherein R1, R2 and R3 represent each a hydrogen or C1-C8 alkyl group; R4 represents an ethyl, 2-fluoroethyl, vinyl, isopropyl, isopropenyl or cyclopropyl group; and X represents CH, C-F, C-Cl or N characterized in that R2 and R3 are not hydrogen at the same time.

  本发明提供了具有相当高抗菌活性的新型吡啶羧酸衍生物。这些衍生物具有下式： 其中 R1、R2 和 R3 分别代表氢或 C1-C8 烷基；R4 代表乙基、2-氟乙基、乙烯基、异丙基、异丙烯基或环丙基；X 代表 CH、C-F、C-Cl 或 N。 其特征在于 R2 和 R3 同时不是氢。
• TERTIARY-NITROGEN-ATOM-CONTAINING LACTONE POLYMER HAVING POLYMERIZABLE GROUP, AND METHOD FOR PRODUCING SAME
  申请人：Daicel Corporation

  公开号：EP2963069A1

  公开（公告）日：2016-01-06

  Provided is a novel lactone polymer containing a tertiary nitrogen atom and a polymerizable group. The lactone polymer is useful as a material monomer for various functional polymeric materials. The lactone polymer containing a tertiary nitrogen atom and a polymerizable group according to the present invention is obtained by allowing a compound (A) represented by Formula (1) to react with a polyisocyanate compound (B) and a hydroxy-containing (meth)acrylate compound (C), where Formula (1) is expressed as follows: wherein R1 typically represents a divalent hydrocarbon group; R2 is selected typically from hydrogen and a hydrocarbon group; A1 is selected from a nitrogen-containing heteroaromatic group and a group represented by one of Formulae (2) and (3): wherein R3 and R4 typically represent a hydrocarbon group; and R5 typically represents a hydrocarbon group; A2 represents a C2-C9 straight or branched chain alkylene group; and n represents an integer of 1 to 50.

  本文提供了一种新型内酯聚合物，它含有一个叔氮原子和一个可聚合基团。这种内酯聚合物可用作各种功能聚合物材料的原料单体。根据本发明的含有叔氮原子和可聚合基团的内酯聚合物是通过使式（1）表示的化合物（A）与多异氰酸酯化合物（B）和含羟基的（甲基）丙烯酸酯化合物（C）反应而得到的，其中式（1）表示如下： 其中 R1 通常代表二价烃基；R2 通常选自氢和烃基；A1 选自含氮杂芳香族基团和由式(2)和(3)之一代表的基团： 其中 R3 和 R4 通常代表烃基；R5 通常代表烃基；A2 代表 C2-C9 直链或支链亚烷基；n 代表 1 至 50 的整数。