3-(2-amino-6-(benzyloxy)-9H-purin-8-yl)propanoic acid | 1292801-96-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 3-(2-amino-6-(benzyloxy)-9H-purin-8-yl)propanoic acid
• CAS: 1292801-96-7
• 化学式: C₁₅H₁₅N₅O₃
• 分子量: 313.316
• InChiKey: DPIPMDMABYODOO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.53
• 重原子数：
  23.0
• 可旋转键数：
  6.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  127.01
• 氢给体数：
  3.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  3-(2-amino-6-(benzyloxy)-9H-purin-8-yl)propanoic acid 在 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 、 二甲基亚砜 为溶剂， 反应 4.0h， 生成 tert-butyl 2-(3-(2-amino-6-(benzyloxy)-9H-purin-8-yl)propanamido)ethylcarbamate
  参考文献：
  名称：

  Real-Time Measurements of Protein Dynamics Using Fluorescence Activation-Coupled Protein Labeling Method

  摘要：

  We present a fluorescence activation-coupled protein labeling (FAPL) method, which employs small-molecular probes that exhibit almost no basal fluorescence but acquire strong fluorescence upon covalent binding to tag-proteins. This method enables real-time imaging of protein labeling without any washout process and is uniquely suitable for real-time imaging of protein dynamics on the cell surface. We applied this method to address the spatiotemporal dynamics of the EGF receptor during cell migration.

  DOI：

  10.1021/ja200225m
• 作为产物：
  描述：

  methyl 3-(2-amino-6-(benzyloxy)-9H-purin-8-yl)propanoate 在 potassium hydroxide 、 溶剂黄146 作用下， 以 甲醇 、 水 为溶剂， 以76%的产率得到3-(2-amino-6-(benzyloxy)-9H-purin-8-yl)propanoic acid
  参考文献：
  名称：

  Real-Time Measurements of Protein Dynamics Using Fluorescence Activation-Coupled Protein Labeling Method

  摘要：

  We present a fluorescence activation-coupled protein labeling (FAPL) method, which employs small-molecular probes that exhibit almost no basal fluorescence but acquire strong fluorescence upon covalent binding to tag-proteins. This method enables real-time imaging of protein labeling without any washout process and is uniquely suitable for real-time imaging of protein dynamics on the cell surface. We applied this method to address the spatiotemporal dynamics of the EGF receptor during cell migration.

  DOI：

  10.1021/ja200225m