4-(4-(benzyloxy)phenyl)-7-(4,5-bis(benzyloxy)-2-chlorophenyl)-5-(methoxymethoxy)benzo-[d][1,3]dioxol-6-yl formate | 1192737-23-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(4-(benzyloxy)phenyl)-7-(4,5-bis(benzyloxy)-2-chlorophenyl)-5-(methoxymethoxy)benzo-[d][1,3]dioxol-6-yl formate
• 英文别名: [4-[2-Chloro-4,5-bis(phenylmethoxy)phenyl]-6-(methoxymethoxy)-7-(4-phenylmethoxyphenyl)-1,3-benzodioxol-5-yl] formate
• CAS: 1192737-23-7
• 化学式: C₄₃H₃₅ClO₉
• 分子量: 731.198
• InChiKey: ZFWSRDZULWOLKT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.7
• 重原子数：
  53
• 可旋转键数：
  16
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  90.9
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  4-(4-(benzyloxy)phenyl)-7-(4,5-bis(benzyloxy)-2-chlorophenyl)-5-(methoxymethoxy)benzo-[d][1,3]dioxol-6-yl formate 在 吡啶 、 copper(I) oxide 作用下， 反应 5.0h， 以88%的产率得到7,8-bis(benzyloxy)-3-(4-(benzyloxy)phenyl)-4-(methoxymethoxy)-1,2-methylenedioxydibenzofuran
  参考文献：
  名称：

  Expeditious Synthesis of Vialinin B, an Extremely Potent Inhibitor of TNF-α Production

  摘要：

  A first total synthesis of vialinin B, a powerful inhibitor (IC50 20 pM) of TNF-alpha production, is described. The key reactions include a double Suzuki-Miyaura coupling of electron-rich aryl bromide with a couple of phenylboronic acids, a Cu-mediated Ullmann reaction, and a LHMDS-promoted phenylacetylation. This synthesis proceeded in 11 steps with 18% overall yield from a known sesamol derivative.

  DOI：

  10.1021/ol9020833
• 作为产物：
  描述：

  7-(4-(benzyloxy)phenyl)-4-(4,5-bis(benzyloxy)-2-chlorophenyl)-6-(methoxymethoxy)benzo-[d][1,3]dioxole-5-carbaldehyde 在 potassium fluoride 、 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 反应 1.33h， 以78%的产率得到4-(4-(benzyloxy)phenyl)-7-(4,5-bis(benzyloxy)-2-chlorophenyl)-5-(methoxymethoxy)benzo-[d][1,3]dioxol-6-yl formate
  参考文献：
  名称：

  Expeditious Synthesis of Vialinin B, an Extremely Potent Inhibitor of TNF-α Production

  摘要：

  A first total synthesis of vialinin B, a powerful inhibitor (IC50 20 pM) of TNF-alpha production, is described. The key reactions include a double Suzuki-Miyaura coupling of electron-rich aryl bromide with a couple of phenylboronic acids, a Cu-mediated Ullmann reaction, and a LHMDS-promoted phenylacetylation. This synthesis proceeded in 11 steps with 18% overall yield from a known sesamol derivative.

  DOI：

  10.1021/ol9020833

文献信息

• Expeditious Synthesis of Vialinin B, an Extremely Potent Inhibitor of TNF-α Production
  作者：Yue Qi Ye、Hiroyuki Koshino、Jun-ichi Onose、Kunie Yoshikawa、Naoki Abe、Shunya Takahashi

  DOI：10.1021/ol9020833

  日期：2009.11.5

  A first total synthesis of vialinin B, a powerful inhibitor (IC50 20 pM) of TNF-alpha production, is described. The key reactions include a double Suzuki-Miyaura coupling of electron-rich aryl bromide with a couple of phenylboronic acids, a Cu-mediated Ullmann reaction, and a LHMDS-promoted phenylacetylation. This synthesis proceeded in 11 steps with 18% overall yield from a known sesamol derivative.