N-benzothiazol-6-yl(tert-butoxy)-N-(4-cyano-5-hydroxy-6-methyl(pyrazolo[1,5-a]pyridin-7-yl))carboxamide | 912543-03-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: N-benzothiazol-6-yl(tert-butoxy)-N-(4-cyano-5-hydroxy-6-methyl(pyrazolo[1,5-a]pyridin-7-yl))carboxamide
• CAS: 912543-03-4
• 化学式: C₂₁H₁₉N₅O₃S
• 分子量: 421.48
• InChiKey: LGXFZMBPLXYFFZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  30.0
• 可旋转键数：
  2.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  103.75
• 氢给体数：
  1.0
• 氢受体数：
  8.0

文献信息

• Pyrazolo[1,5-a]pyridine derivatives or pharmaceutically acceptable salts thereof
  申请人：Unoki Gen

  公开号：US20070072898A1

  公开（公告）日：2007-03-29

  A pyrazolo[1,5-a]pyridine derivative represented by formula (I) and salt thereof exhibit excellent MAPKAP-K2 inhibitory activity. Accordingly, medicines comprising this compound as an active ingredient are expected to be valuable for treating or preventing diseases mediated by MAPKAP-K2 such as inflammatory injury, autoimmune diseases, asteropathia destruens, cancer and/or growth of tumor.

  由式(I)表示的吡唑并[1,5-a]吡啶衍生物及其盐表现出优异的MAPKAP-K2抑制活性。因此，包含该化合物作为活性成分的药物预计对治疗或预防由MAPKAP-K2介导的疾病，如炎症损伤、自身免疫疾病、asteropathia destruens、癌症和/或肿瘤生长具有重要价值。
• PYRAZOLO[1,5-a]PYRIDINE DERIVATIVE OR MEDICALLY ACCEPTABLE SALT THEREOF
  申请人：Teijin Pharma Limited

  公开号：EP1873154A1

  公开（公告）日：2008-01-02

  A pyrazolo[1,5-a]pyridine derivative represented by formula (I) and salt thereof exhibit excellent MAPKAP-K2 inhibitory activity. Accordingly, medicines comprising this compound as an active ingredient are expected to be valuable for treating or preventing diseases mediated by MAPKAP-K2 such as inflammatory injury, autoimmune diseases, asteropathia destruens, cancer and/or growth of tumor.

  由式（I）代表的吡唑并[1,5-a]吡啶衍生物及其盐具有优异的 MAPKAP-K2 抑制活性。因此，以该化合物为活性成分的药物有望用于治疗或预防由 MAPKAP-K2 介导的疾病，如炎症损伤、自身免疫性疾病、淀粉样变性、癌症和/或肿瘤生长。
• US7417053B2
  申请人：——

  公开号：US7417053B2

  公开（公告）日：2008-08-26