adamantan-1-yl-[7-thiazol-2-yl-2H-chromen-3-yl]-methanone | 881853-08-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: adamantan-1-yl-[7-thiazol-2-yl-2H-chromen-3-yl]-methanone
• 英文别名: 1-adamantyl-[7-(1,3-thiazol-2-yl)-2H-chromen-3-yl]methanone
• CAS: 881853-08-3
• 化学式: C₂₃H₂₃NO₂S
• 分子量: 377.507
• InChiKey: BWOMESHMSVPKOB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  67.4
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Cyclic and acyclic propenones for treating CNS disorders
  申请人：Kalvinsh Ivars

  公开号：US20060074083A1

  公开（公告）日：2006-04-06

  The invention relates to novel cyclic and non-cyclic propenone derivatives as well as their pharmaceutically acceptable slats. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are useful as medicaments.

  该发明涉及新颖的环状和非环状丙烯酮衍生物以及它们的药用可接受盐。该发明还涉及一种制备这类化合物的方法。该发明的化合物可用作药物。
• NOVEL CYCLIC AND ACYCLIC PROPENONES FOR TREATING CNS DISORDERS
  申请人：Merz Pharma GmbH & Co.KGaA

  公开号：EP1804781A1

  公开（公告）日：2007-07-11
• [EN] NOVEL CYCLIC AND ACYCLIC PROPENONES FOR TREATING CNS DISORDERS<br/>[FR] NOUVELLES PROPENONES CYCLIQUES ET ACYCLIQUES DESTINEES AU TRAITEMENT DES TROUBLES DU SNC
  申请人：MERZ PHARMA GMBH & CO KGAA

  公开号：WO2006037996A1

  公开（公告）日：2006-04-13

  The invention relates to novel cyclic and non-cyclic propenone derivatives as well as their pharmaceutically acceptable salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are useful as medicaments.