| 1228152-72-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• CAS: 1228152-72-4
• 化学式: C₇₀H₈₈N₄O₂Zn
• 分子量: 1082.88
• InChiKey: WYZLBDMOUVCOBQ-SFJKGPFBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  在 potassium hydroxide 作用下， 以 甲苯 为溶剂， 生成 bis-1,15-(1,4-ethynylbenzene)-3,7,13,17-tetramethyl-2,8,12,18-tetrakis(n-hexyl) zinc(II) porphyrin
  参考文献：
  名称：

  Synthesis of new building blocks for use in supramolecular DNA architectures

  摘要：

  New nucleoside building blocks for the synthesis of functional DNA are presented. A porphyrin-bis nucleoside dU-porphyrin-dU was synthesised from a di-acetylene-substituted porphyrin using Sonogashira coupling with 5-iodo deoxy uridine. The same strategy was used to obtain a new terpy-functionalised nucleoside dU(terpy). This building block can be metallated with ruthenium(II) either to make a mono-nucleoside ruthenium complex (dU(terpy)) Ru-II(terpy), or to connect two building blocks to create a bis-nucleoside (dU(terpy))(2)Ru-II. The terpy nucleoside building block dU(terpy) was incorporated into short strands of DNA to give TXT, TXXT and TXXXT as sequences (X = dU(terpy)). The functionalised DNA has the potential to create supramolecular assemblies through metal complexation.

  DOI：

  10.1080/10610270903304418
• 作为产物：
  描述：

  在 zinc diacetate 作用下， 以 甲醇 、 氯仿 为溶剂， 以100%的产率得到
  参考文献：
  名称：

  Synthesis of new building blocks for use in supramolecular DNA architectures

  摘要：

  New nucleoside building blocks for the synthesis of functional DNA are presented. A porphyrin-bis nucleoside dU-porphyrin-dU was synthesised from a di-acetylene-substituted porphyrin using Sonogashira coupling with 5-iodo deoxy uridine. The same strategy was used to obtain a new terpy-functionalised nucleoside dU(terpy). This building block can be metallated with ruthenium(II) either to make a mono-nucleoside ruthenium complex (dU(terpy)) Ru-II(terpy), or to connect two building blocks to create a bis-nucleoside (dU(terpy))(2)Ru-II. The terpy nucleoside building block dU(terpy) was incorporated into short strands of DNA to give TXT, TXXT and TXXXT as sequences (X = dU(terpy)). The functionalised DNA has the potential to create supramolecular assemblies through metal complexation.

  DOI：

  10.1080/10610270903304418