1-(2,3-dideoxy-β-D-glyceropent-2-enofuranosyl)pyrazin-2-one | 1190096-27-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1-(2,3-dideoxy-β-D-glyceropent-2-enofuranosyl)pyrazin-2-one
• 英文别名: 1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]pyrazin-2-one
• CAS: 1190096-27-5
• 化学式: C₉H₁₀N₂O₃
• 分子量: 194.19
• InChiKey: NRDDZJFJYMNPGA-IONNQARKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  62.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-(5-benzoyl-2,3-dideoxy-β-D-glyceropent-2-enofuranosyl)pyrazin-2-one 在 甲醇 、 氨 作用下， 反应 72.0h， 以95%的产率得到1-(2,3-dideoxy-β-D-glyceropent-2-enofuranosyl)pyrazin-2-one
  参考文献：
  名称：

  3-Substituted Pyrazinone Nucleosides—A New Family of D4T Analogues

  摘要：

  The synthesis of a new family of D4T analogues is described to study the influence of pyrazinone base on antiretroviral power. Substitution of 3H by methyl or n-decyl increases the lipophilic character and may facilitate diffusion across cell membranes. The compounds were characterized by H-1 NMR and infrared spectroscopy. Antiviral (HIV-1) properties of these compounds were examined.

  DOI：

  10.1080/15257770903169999

文献信息

• 3-Substituted Pyrazinone Nucleosides—A New Family of D4T Analogues
  作者：Nathalie Batoux、Robert Granet、Rachida Zerrouki、Pierre Krausz

  DOI：10.1080/15257770903169999

  日期：2009.9.17

  The synthesis of a new family of D4T analogues is described to study the influence of pyrazinone base on antiretroviral power. Substitution of 3H by methyl or n-decyl increases the lipophilic character and may facilitate diffusion across cell membranes. The compounds were characterized by H-1 NMR and infrared spectroscopy. Antiviral (HIV-1) properties of these compounds were examined.