3-甲基-2-氮杂螺[4.4]壬烷 | 914223-79-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 中文名称: 3-甲基-2-氮杂螺[4.4]壬烷
• 英文名称: 3-methyl-2-aza-spiro[4,4]nonane
• 英文别名: 3-Methyl-2-azaspiro[4.4]nonane
• CAS: 914223-79-3
• 化学式: C₉H₁₇N
• mdl: MFCD09032721
• 分子量: 139.241
• InChiKey: NPBBRURTAYRIQO-UHFFFAOYSA-N

物化性质

• 沸点：
  192.1±8.0 °C(Predicted)
• 密度：
  0.93±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  2-噻吩磺酰氯 、 3-甲基-2-氮杂螺[4.4]壬烷 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 以78 %的产率得到3-methyl-2-(thiophen-2-ylsulfonyl)-2-azaspiro[4.4]nonane
  参考文献：
  名称：

  [EN] SPIROCYCLIC CAV2.3 ANTAGONISTS
  [FR] ANTAGONISTES DE CAV2.3 SPIROCYCLIQUES

  摘要：

  Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof wherein X1, R3, R4, a, b, p, q, r, L, and Ring A are as defined herein. The compounds are antagonists of the resistant (R-type) voltage-gated calcium ion channel Cav 2.3. Also disclosed are pharmaceutical compositions comprising the compounds; and the compounds for use in the treatment of diseases modulated Cav 2.3, including neurodegenerative conditions such as Parkinson's disease, focal, drug-resistant forms of epilepsy, and other neurological disorders such as developmental and epileptic encephalopathies and Fragile X syndrome.

  公开号：

  WO2023094827A1
• 作为产物：
  描述：

  (1-allylcyclopentyl)methanamine 在 [Li(thf)4][Yb{(R)-C₂₀H₁₂N₂(C₁₀H₁₈)}2] 作用下， 以 氘代苯 为溶剂， 反应 15.0h， 生成 3-甲基-2-氮杂螺[4.4]壬烷
  参考文献：
  名称：

  新型手性镧系元素酰胺络合物，用于催化合成规模化的含氮杂环。

  摘要：

  合成并表征了具有锂和钾抗衡离子的新型手性联萘并钇盐和and盐配合物。[Li（thf）4] [Ln {（R）-C20H12（NC5H9）2} 2]（Ln = Yb，Y）和[K（thf）5] [Yb {（R ）-C20H12（NCH2CMe3）2} 2]为同构络合物。检查了这些络合物对对映选择性分子内胺化的效率。[Li（thf）4] [Yb {（R）-C20H12（NC5H9）2} 2]提供了最高的对映体过量（最多87％），用于合成螺吡咯烷，而[Li（thf）4] [Y {（R）-C20H12（NC5H9）2} 2]的活性更高。锂和钾盐配合物之间的比较证明了抗衡阳离子在活性催化物质中的作用。该系列中活性最高的催化剂[Li（thf）4] [Yb {（R）-C20H12（NCH2CMe3）2} 2]，

  DOI：

  10.1002/chem.200701090

文献信息

• SUBSTITUTED ARYL AND HETEROARYL CARBOXYLIC ACID HYDRAZIDES OR SALTS THEREOF AND USE THEREOF TO INCREASE STRESS TOLERANCE IN PLANTS
  申请人：BAYER CROPSCIENCE AKTIENGESELLSCHAFT

  公开号：US20180206495A1

  公开（公告）日：2018-07-26

  Substituted aryl- and heteroarylcarbonyl hydrazides The invention relates to substituted aryl- and heteroarylcarbonyl hydrazides of the general formula (I) or salts thereof where the radicals of the formula (I) are each as defined in the description for enhancing stress tolerance in plants to abiotic stress, and for enhancing plant growth and/or for increasing plant yield.

  该发明涉及通式（I）的取代芳基和杂芳基羰基肼或其盐，其中通式（I）的基团如描述中所定义，用于增强植物对非生物胁迫的耐受性，促进植物生长和/或增加植物产量。
• SUBSTITUTED HETEROARYL CARBOXYLIC ACID HYDRAZIDES OR SALTS THEREOF AND USE THEREOF TO INCREASE STRESS TOLERANCE IN PLANTS
  申请人：Bayer CropScience Aktiengesellschaft

  公开号：US20180206498A1

  公开（公告）日：2018-07-26

  The invention relates to substituted heteroaryl carboxylic acid hydrazides of general formula (I) or salts thereof, wherein the groups of formula (I) have the definitions stated in the description, for increasing the stress tolerance in plants with respect to abiotic stress, and also for strengthening plant growth and/or for increasing plant yield.

  该发明涉及通式（I）的取代杂环芳基羧酸腙或其盐，其中通式（I）中的基团具有描述中所述的定义，用于增加植物对非生物胁迫的耐受性，同时也用于增强植物生长和/或增加植物产量。
• SUBSTITUTED 2-HETEROARYLOXYPYRIDINES AND SALTS THEREOF AND THEIR USE AS HERBICIDAL AGENTS
  申请人：Bayer Aktiengesellschaft

  公开号：US20210276974A1

  公开（公告）日：2021-09-09

  Substituted 2-heteroaryloxypyridines and salts thereof and use thereof as herbicidal active substances Substituted 2-heteroaryloxypyridines of the general formula (I) are described, and their use as herbicides, in particular for controlling broad-leaved weeds and/or weed grasses in crops of useful plants and/or as plant growth regulators for influencing the growth of crops of useful plants. The present invention further relates to herbicidal and/or plant growth-regulating compositions comprising one or more compounds of the general formula (I).

  2-杂环氧基吡啶及其盐的替代物及其作为除草活性物质的用途被描述，一般式(I)的2-杂环氧基吡啶的替代物被描述，并且它们作为除草剂的用途，特别是用于控制作物中的阔叶杂草和/或杂草草本植物，或者作为植物生长调节剂，以影响作物的生长。本发明还涉及包含一种或多种一般式(I)化合物的除草剂和/或植物生长调节剂组合物。
• SUBSTITUTED THIOPHENYL URACILS, SALTS THEREOF AND THE USE THEREOF AS HERBICIDAL AGENTS
  申请人：Syngenta Crop Protection AG

  公开号：US20200315174A1

  公开（公告）日：2020-10-08

  The invention relates to substituted thiophenyl uracils of general formula (I) or the salts (I) thereof, wherein the groups in general formula (I) are as defined in the description, and to the use thereof as herbicides, in particular for controlling weeds and/or weed grasses in crops of cultivated plants and/or as plant growth regulators for influencing the growth of crops of cultivated plants.

  本发明涉及取代噻吩基尿嘧啶的通式(I)或其盐(I)，其中通式(I)中的基团如描述中定义，以及作为除草剂，特别是用于控制作物中的杂草和/或杂草草本的用途，以及作为植物生长调节剂用于影响栽培植物作物的生长。
• SUBSTITUTED CYANO CYCLOALKYL PENTA-2,4-DIENES, CYANO CYCLOALKYL PENT-2-EN-4-YNES, CYANO HETEROCYCLYL PENTA-2,4-DIENES AND CYANO HETEROCYCLYL PENT-2-EN-4-YNES AS ACTIVE SUBSTANCES
  申请人：BAYER CROPSCIENCE AKTIENGESELLSCHAFT

  公开号：US20170210701A1

  公开（公告）日：2017-07-27

  The invention relates to cyano cycloalkyl penta-2,4-dienes, cyano cycloalkyl pent-2-en-4-ynes, cyano heterocyclyl penta-2,4-dienes and cyano heterocyclyl pent-2-en-4-ynes of general formula (I), or the salts thereof, where [X-Y], Q, R 1 , R 2 , A 1 , A 2 , V, W, m and n have the definitions specified in the description. The invention also relates to a production method for same and to the use of same for increasing stress tolerance in plants against abiotic stress, and/or for increasing the plant yield.

  该发明涉及一般式(I)的氰基环烷基戊二烯、氰基环烷基戊-2-炔、氰基杂环烷基戊二烯和氰基杂环烷基戊-2-炔，或其盐，其中[X-Y]、Q、R1、R2、A1、A2、V、W、m和n的定义如描述中所指定。该发明还涉及同类物质的生产方法以及将其用于增加植物对非生物胁迫的抗逆性和/或增加植物产量。