3-Methyl-1,2,3,4-tetrahydroisochinolin-1,4-dion | 90924-10-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 3-Methyl-1,2,3,4-tetrahydroisochinolin-1,4-dion
• 英文别名: 3-Methyl-2,3-dihydroisoquinoline-1,4-dione
• CAS: 90924-10-0
• 化学式: C₁₀H₉NO₂
• 分子量: 175.187
• InChiKey: VAXPFPYGNZQQTK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Heteroarylaminosulfonylphenyl derivatives for use as sodium or calcium channel blockers in the treatment of pain
  申请人：VERTEX PHARMACEUTICALS INCORPORATED

  公开号：EP2327701A1

  公开（公告）日：2011-06-01

  The present invention relates to compounds of formula (IV) useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

  本发明涉及作为电压门控钠通道抑制剂的式 (IV) 化合物。本发明还提供了包含本发明化合物的药学上可接受的组合物，以及使用该组合物治疗各种疾病的方法。
• Heteroarylaminosulfonylphenylderivates for use as sodium or calcium channel blockers in the treatment of pain
  申请人：VERTEX PHARMACEUTICALS INCORPORATED

  公开号：EP2332912A1

  公开（公告）日：2011-06-15

  The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

  本发明涉及可用作电压门控钠通道抑制剂的化合物。本发明还提供了包含本发明化合物的药学上可接受的组合物，以及使用该组合物治疗各种疾病的方法。
• [EN] COMPOSITIONS USEFUL AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS<br/>[FR] COMPOSITIONS UTILISEES COMME INHIBITEURS DE CANAUX SODIUM VOLTAGE DEPENDANTS
  申请人：VERTEX PHARMA

  公开号：WO2005013914A2

  公开（公告）日：2005-02-17

  The present invention relates to compounds such as those of formula (I-A) inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, such as pain.