5,6-二氯苯并咪唑盐酸盐 | 1087737-96-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 中文名称: 5,6-二氯苯并咪唑盐酸盐
• 英文名称: 5,6-Dichlorobenzimidazole Hydrochloride
• 英文别名: 5,6-dichloro-1H-benzimidazole;hydrochloride
• CAS: 1087737-96-9
• 化学式: C7H5Cl3N2
• 分子量: 223.5
• InChiKey: CKILENXYURTTFP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.29
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  28.7
• 氢给体数：
  2
• 氢受体数：
  1

安全信息

• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H315,H319,H335

文献信息

• HYBRIDIZING ALL-LNA OLIGONUCLEOTIDES
  申请人：F. Hoffmann-La Roche AG

  公开号：EP3980554A1

  公开（公告）日：2022-04-13
• HYBRIDIZING all-LNA OLIGONUCLEOTIDES
  申请人：Roche Diagnostics Operations, Inc.

  公开号：US20220195497A1

  公开（公告）日：2022-06-23

  The present report relates to hybridizing single-stranded (ss-) oligonucleotides which entirely consist of locked nucleic acid (LNA) monomers. The present document shows hybridization experiments with pairs of entirely complementary ss-oligonucleotides which fail to form a duplex within a given time interval. The present report provides methods to identify such incompatible oligonucleotide pairs. In another aspect, the present report provides pairs of complementary ss-oligonucleotides which are capable of rapid duplex formation. The present report also provides methods to identify and select compatible oligonucleotide pairs. In yet another aspect the present report provides use of compatible oligonucleotide pairs as binding partners in binding assays, e.g. receptor-based assays.
• [EN] HYBRIDIZING ALL-LNA OLIGONUCLEOTIDES<br/>[FR] HYBRIDATION D'OLIGONUCLÉOTIDES TOUT-LNA
  申请人：HOFFMANN LA ROCHE

  公开号：WO2020245377A1

  公开（公告）日：2020-12-10

  The present report relates to hybridizing single-stranded (ss-) oligonucleotides which entirely consist of locked nucleic acid (LNA) monomers. The present document shows hybridization experiments with pairs of entirely complementary ss- oligonucleotides which fail to form a duplex within a given time interval. The present report provides methods to identify such incompatible oligonucleotide pairs. In another aspect, the present report provides pairs of complementary ss- oligonucleotides which are capable of rapid duplex formation. The present report also provides methods to identify and select compatible oligonucleotide pairs. In yet another aspect the present report provides use of compatible oligonucleotide pairs as binding partners in binding assays, e.g. receptor-based assays.