[2-(6-chloro-pyridin-2-yl)-quinazolin-4-yl]-cyclohexyl-amine | 942984-09-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: [2-(6-chloro-pyridin-2-yl)-quinazolin-4-yl]-cyclohexyl-amine
• 英文别名: 2-(6-chloropyridin-2-yl)-N-cyclohexylquinazolin-4-amine
• CAS: 942984-09-0
• 化学式: C₁₉H₁₉ClN₄
• 分子量: 338.84
• InChiKey: FWMJAPATBKENDT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  50.7
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• 2-PYRIDIN-2-YL-QUINAZOLINE DERIVATIVES AS POTASSIUM CHANNEL MODULATING AGENTS FOR THE TREATMENT OF RESPIRATORY DISEASES
  申请人：Eriksen Birgitte L.

  公开号：US20090306102A1

  公开（公告）日：2009-12-10

  This invention relates to novel pyridinyl-quinazoline derivatives and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels.

  该发明涉及新型吡啶基喹唑啉衍生物及其作为钾通道调节剂的用途。此外，该发明还涉及用于治疗或缓解与钾通道活性相关的疾病或紊乱的药物组合物。
• PYRIDINYL-QUINAZOLINE DERIVATIVES AND THEIR MEDICAL USE
  申请人：NeuroSearch A/S

  公开号：EP1966184A2

  公开（公告）日：2008-09-10
• [EN] PYRIDINYL-QUINAZOLINE DERIVATIVES AND THEIR MEDICAL USE<br/>[FR] DERIVES DE PYRIDINYL-QUINAZOLINE ET LEUR UTILISATION MEDICALE
  申请人：NEUROSEARCH AS

  公开号：WO2007071632A2

  公开（公告）日：2007-06-28

  [EN] This invention relates to novel pyridinyl-quinazoline derivatives and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels.
  [FR] La présente invention concerne de nouveaux dérivés de pyridinyl-quinazoline et leur utilisation en tant qu'agents modulateurs de canal potassique. De plus, l'invention concerne des compositions pharmaceutiques utiles pour le traitement ou l'atténuation de maladies ou troubles associés à l'activité de canaux potassiques.