7-chloro-5-piperidin-1-yl-6-(2,4,6-trifluorophenyl)imidazo[1,2-a]pyrimidine | 502500-34-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 7-chloro-5-piperidin-1-yl-6-(2,4,6-trifluorophenyl)imidazo[1,2-a]pyrimidine
• 英文别名: 5-(piperidin-1-yl)-6-(2,4,6-trifluorophenyl)-7-chloroimidazo[1,2-a]pyrimidine
• CAS: 502500-34-7
• 化学式: C₁₇H₁₄ClF₃N₄
• 分子量: 366.773
• InChiKey: NVKCYJNBXGAKLO-UHFFFAOYSA-N

物化性质

• 密度：
  1.52±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  33.4
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• 6-Aryl-7-halo-imidazo[1,2-a]pyrimidines as anticancer agents
  申请人：Zhang Nan

  公开号：US20050065167A1

  公开（公告）日：2005-03-24

  This invention relates to certain 6-aryl-7-halo-imidazo[1,2-a]pyrimidines or pharmaceutically acceptable salts thereof, and compositions containing said compounds or pharmaceutically acceptable salts thereof, wherein said compounds are anti-cancer agents useful for the treatment of cancer in mammals by promotion of microtubule polymerization. This invention further relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal and further provides a method for the treatment or prevention of cancerous tumors that express multiple drug resistance (MDR) or are resistant because of MDR, in a mammal in need thereof which method comprises administering to said mammal an effective amount of said compounds or pharmaceutically acceptable salts thereof.

  本发明涉及某些6-芳基-7-卤代咪唑[1,2-a]嘧啶或其药学上可接受的盐以及含有该化合物或其药学上可接受的盐的组合物，其中该化合物是抗癌剂，可通过促进微管聚合来治疗哺乳动物的癌症。本发明还涉及一种治疗或抑制哺乳动物中癌细胞的生长和相关疾病的方法，并进一步提供了一种用于治疗或预防表达多药耐药性（MDR）或因MDR而耐药的癌症肿瘤的方法，该方法包括向所述哺乳动物施用所述化合物或其药学上可接受的盐的有效量。
• Imidazo[1,2-a]pyrimidine and fungicidal compositions containing thereof
  申请人：——

  公开号：US20040235865A1

  公开（公告）日：2004-11-25

  The imidazo[1,2-a]pyrimidines given by the following formula [I]: 1 wherein R 1 and R 2 represent a C1-C6 alkyl group optionally substituted by one or more selected from the group consisting of C1-C4 alkoxy group, C2-C8 dialkylamino group, C1-C4 alkylthio group, C2-C5 alkoxycarbonyl group, cyano group and halogen atoms; or R 1 and R 2 represent a 3-8 membered heterocyclic group together with the nitrogen atom bonded with R 1 and R 2 ; R 3 represents a halogen atom or C1-C4 alkyl group; and Ar represents a phenyl group optionally substituted by a halogen atom or atoms; and the like] have excellent activity for controlling plant diseases.

  以下式子所示的咪唑[1,2-a]嘧啶化合物 [I]:1具有出色的植物病害控制活性，其中：R1和R2代表C1-C6烷基，可选地被来自C1-C4烷氧基、C2-C8二烷基氨基、C1-C4烷硫基、C2-C5烷氧羰基、氰基和卤素原子的一个或多个选择性取代；或者R1和R2与与其相结合的氮原子共同构成3-8成员的杂环基团；R3代表卤素原子或C1-C4烷基；Ar代表苯基，可选地被一个或多个卤素原子取代；等等。
• IMIDAZO(1,2-a)PYRIMIDINES AND FUNGICIDE COMPOSITIONS CONTAINING THE SAME
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP1431299B1

  公开（公告）日：2007-05-23
• 6-ARYL-7-HALO-IMIDAZO[1,2-A]PYRIMIDINES AS ANTICANCER AGENT
  申请人：Wyeth Holdings Corporation

  公开号：EP1684763A1

  公开（公告）日：2006-08-02
• US7211545B2
  申请人：——

  公开号：US7211545B2

  公开（公告）日：2007-05-01