2-[(1S)-2-amino-1-(3-pyrimidin-5-ylbenzyl)ethyl]-5-(1-methyl-1H-pyrazol-5-yl)isoindolin-1-one | 1430057-30-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-[(1S)-2-amino-1-(3-pyrimidin-5-ylbenzyl)ethyl]-5-(1-methyl-1H-pyrazol-5-yl)isoindolin-1-one
• 英文别名: 2-[(2S)-1-amino-3-(3-pyrimidin-5-ylphenyl)propan-2-yl]-5-(2-methylpyrazol-3-yl)-3H-isoindol-1-one
• CAS: 1430057-30-9
• 化学式: C₂₅H₂₄N₆O
• 分子量: 424.505
• InChiKey: GRECDSLEFFILAF-QFIPXVFZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  89.9
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• ISOINDOLINONE AND PYRROLOPYRIDINONE DERIVATIVES AS AKT INHIBITORS
  申请人：Incyte Corporation

  公开号：US20130096144A1

  公开（公告）日：2013-04-18

  The present invention provides isoindolinone and pyrrolopyridinone derivatives, as well as their compositions and methods of use, that inhibit the activity of the serine/threonine kinase, Akt, and are useful in the treatment of diseases related to the activity of Akt including, for example, cancer and other diseases.

  本发明提供了异吲哚酮和吡咯吡啶酮衍生物，以及它们的组合物和使用方法，这些衍生物抑制丝氨酸/苏氨酸激酶Akt的活性，对于治疗与Akt活性相关的疾病，例如癌症和其他疾病，具有益处。
• US8895571B2
  申请人：——

  公开号：US8895571B2

  公开（公告）日：2014-11-25
• [EN] ISOINDOLINONE AND PYRROLOPYRIDINONE DERIVATIVES AS AKT INHIBITORS<br/>[FR] DÉRIVÉS D'ISOINDOLINONE ET DE PYRROLOPYRIDINONE EN TANT QU'INHIBITEURS D'AKT
  申请人：INCYTE CORP

  公开号：WO2013056015A1

  公开（公告）日：2013-04-18

  The present invention provides isoindolinone and pyrrolopyridinone derivatives, as well as their compositions and methods of use, that inhibit the activity of the serine/threonine kinase, Akt, and are useful in the treatment of diseases related to the activity of Akt including, for example, cancer and other diseases.