6-amino-2-(butylamino)-9-[3-(4-cyclohexyl-1-piperazinyl)propyl]-7,9-dihydro-8H-purin-8-one | 1207679-87-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 6-amino-2-(butylamino)-9-[3-(4-cyclohexyl-1-piperazinyl)propyl]-7,9-dihydro-8H-purin-8-one
• 英文别名: 6-amino-2-(butylamino)-9-[3-(4-cyclohexylpiperazin-1-yl)propyl]-7H-purin-8-one
• CAS: 1207679-87-5
• 化学式: C₂₂H₃₈N₈O
• 分子量: 430.597
• InChiKey: KISPQWDTMVKGIT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  31
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  103
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• [EN] PURINE DERIVATIVES FOR USE IN THE TREATMENT OF ALLERGIC, INFLAMMATORY AND INFECTIOUS DISEASES<br/>[FR] DÉRIVÉS PURINES DESTINÉS À ÊTRE UTILISÉS DANS LE TRAITEMENT DE MALADIES ALLERGIQUES, INFLAMMATOIRES ET INFECTIEUSES
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2010018131A1

  公开（公告）日：2010-02-18

  Compounds of Formula (I): wherein R1 is C1-6alkylamino, C1-6alkoxy, or C3-7cycloalkyloxy; m is an integer having a value of 2 to 6; R2 is hydrogen, C1-6alkyl, or C3-7cycloalkylC0-6alkyl; and salts thereof are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, the treatment of infectious diseases and cancer, and may also be useful as vaccine adjuvants.

  化合物的化学式（I）：其中R1是C1-6烷基氨基，C1-6烷氧基或C3-7环烷氧基；m是一个整数，取值为2到6；R2是氢，C1-6烷基或C3-7环烷基C0-6烷基；以及它们的盐是人类干扰素的诱导剂。诱导人类干扰素的化合物可能在治疗各种疾病方面有用，例如治疗过敏性疾病和其他炎症性疾病，例如过敏性鼻炎和哮喘，治疗传染病和癌症，也可能作为疫苗佐剂有用。
• PURINE DERIVATIVES FOR USE IN THE TREATMENT OF ALLERGIC, INFLAMMATORY AND INFECTIOUS DISEASES
  申请人：Bazin-Lee Helene

  公开号：US20110135671A1

  公开（公告）日：2011-06-09

  The present invention relates to compounds of formula (I): wherein R 1 is C 1-6 alkylamino, C 1-6 alkoxy, or C 3-7 cycloalkyloxy; m is an integer having a value of 2 to 6; R 2 is hydrogen, C 1-6 alkyl, or C 3-7 cycloalkylC 0-6 alkyl; and salts thereof are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, the treatment of infectious diseases and cancer, and may also be useful as vaccine adjuvants.

  本发明涉及式(I)的化合物：其中R1是C1-6烷基氨基，C1-6烷氧基或C3-7环烷氧基；m是一个整数，其值为2到6；R2是氢，C1-6烷基或C3-7环烷基C0-6烷基；以及它们的盐是人干扰素的诱导剂。诱导人干扰素的化合物可能在治疗各种疾病方面有用，例如治疗过敏性疾病和其他炎症性疾病，例如过敏性鼻炎和哮喘，治疗传染病和癌症，也可能作为疫苗佐剂有用。