Benzyl 2-amino-1,3-thiazole-4-carboxylate | 1416811-55-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Benzyl 2-amino-1,3-thiazole-4-carboxylate
• CAS: 1416811-55-6
• 化学式: C₁₁H₁₀N₂O₂S
• 分子量: 234.279
• InChiKey: GHQNURTVTLLRKY-UHFFFAOYSA-N

物化性质

• 沸点：
  415.1±20.0 °C(Predicted)
• 密度：
  1.354±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  93.4
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Benzyl 2-amino-1,3-thiazole-4-carboxylate 在 benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate 、 N,N-二异丙基乙胺 、 三氟乙酸 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 benzyl 2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-1,3-thiazole-4-carboxylate
  参考文献：
  名称：

  Discovery of novel dual-action antidiabetic agents that inhibit glycogen phosphorylase and activate glucokinase

  摘要：

  Dual-target-directed agents simultaneously inhibiting glycogen phosphorylase (GP) and activating glucokinase (GK) could decelerate the inflow of glucose from glycogenolysis and accelerate the outflow of glucose in the liver, therefore allow for a better control over hyperglycaemia in a synergetic manner. A series of hybrid compounds were designed by structure-assisted and ligand-based strategies. In vitro bioassays found two novel compounds (1j, 6g) worthy of further optimization on balance of dual action to GP and GK. In addition, for single-target activity, two compounds exhibited more potent GP inhibitory activity and four compounds showed better GK activation than their corresponding references. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.06.020
• 作为产物：
  描述：

  2-氨基噻唑-4-甲酸甲酯 、 苯甲醇 在 硫酸 作用下， 反应 0.33h， 生成 Benzyl 2-amino-1,3-thiazole-4-carboxylate
  参考文献：
  名称：

  Discovery of novel dual-action antidiabetic agents that inhibit glycogen phosphorylase and activate glucokinase

  摘要：

  Dual-target-directed agents simultaneously inhibiting glycogen phosphorylase (GP) and activating glucokinase (GK) could decelerate the inflow of glucose from glycogenolysis and accelerate the outflow of glucose in the liver, therefore allow for a better control over hyperglycaemia in a synergetic manner. A series of hybrid compounds were designed by structure-assisted and ligand-based strategies. In vitro bioassays found two novel compounds (1j, 6g) worthy of further optimization on balance of dual action to GP and GK. In addition, for single-target activity, two compounds exhibited more potent GP inhibitory activity and four compounds showed better GK activation than their corresponding references. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.06.020

文献信息

• USE OF ISOXAZOLINE COMPOUNDS IN POULTRY
  申请人：Intervet International B.V.

  公开号：EP3878281A1

  公开（公告）日：2021-09-15

  The present invention relates to methods of treating or preventing arthropod infestations of poultry animals and methods of controlling arthropod infestations in poultry animal's environment by administering an isoxazoline compound of formula (I) via drinking water.

  本发明涉及通过施用式 (I) 的异噁唑啉化合物治疗或预防家禽动物节肢动物侵扰的方法，以及控制家禽动物环境中节肢动物侵扰的方法 通过饮用水。
• TOPICAL LOCALIZED ISOXAZOLINE FORMULATION
  申请人：Intervet International B.V.

  公开号：EP2658542B1

  公开（公告）日：2022-01-26
• [EN] INJECTABLE PHARMACEUTICAL COMPOSITIONS AND USES THEREOF<br/>[FR] COMPOSITIONS PHARMACEUTIQUES INJECTABLES ET LEURS UTILISATIONS
  申请人：INTERVET INT BV

  公开号：WO2020225143A1

  公开（公告）日：2020-11-12

  An injectable pharmaceutical composition comprising an isoxazoline compound of Formula (I), or a salt or N-oxide and moxidectin microspheres and a method of preventing or treating a parasite infestation using the same.
• [EN] SOFT CHEWABLE VETERINARY DOSAGE FORM<br/>[FR] FORME GALÉNIQUE VÉTÉRINAIRE À MÂCHER MOLLE
  申请人：INTERVET INT BV

  公开号：WO2021013825A1

  公开（公告）日：2021-01-28

  The present application relates to a soft chewable veterinary dosage form comprising a systemic parasiticide as well as a physiologically active macrocyclic lactone and to a method for preparing said soft chewable veterinary dosage form.
• [EN] COMPOSITION FOR LICE CONTROL<br/>[FR] COMPOSITION POUR LUTTER CONTRE LES POUX
  申请人：INTERVET INT BV

  公开号：WO2021122513A1

  公开（公告）日：2021-06-24

  The present invention relates to methods of treating or preventing chewing lice infestations of sheep animals by orally administering an isoxazoline compound of formula (I)