(3R)-3-methyl-1,2,3,4-tetrahydro-[1]benzothiolo[3,2-c]pyridine | 223916-07-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并吡啶类
• 英文名称: (3R)-3-methyl-1,2,3,4-tetrahydro-[1]benzothiolo[3,2-c]pyridine
• CAS: 223916-07-2
• 化学式: C₁₂H₁₃NS
• 分子量: 203.308
• InChiKey: NKCVGSDILMNQPS-MRVPVSSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  40.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-benzo[b]thiophen-3-yl-[1,3]dioxolane 在 正丁基锂 、 sodium carbonate 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 3.25h， 生成 (3R)-3-methyl-1,2,3,4-tetrahydro-[1]benzothiolo[3,2-c]pyridine
  参考文献：
  名称：

  Expedient Synthesis of Highly Functionalised Cyclic Imines

  摘要：

  Aryl- and heteroaryl fused cyclic imines are obtained from the starting acetal via a directed metallation-alkylation-condensation sequence using cyclic sulfamidates as the electrophile. A variety of aromatics and heteroaromatics are demonstrated to be applicable to this methodology, which produces highly versatile cyclic imine building blocks for drug discovery and total synthesis programmes.

  DOI：

  10.1055/s-0034-1379918

文献信息

• Expedient Synthesis of Highly Functionalised Cyclic Imines
  作者：Thomas Moss

  DOI：10.1055/s-0034-1379918

  日期：——

  Aryl- and heteroaryl fused cyclic imines are obtained from the starting acetal via a directed metallation-alkylation-condensation sequence using cyclic sulfamidates as the electrophile. A variety of aromatics and heteroaromatics are demonstrated to be applicable to this methodology, which produces highly versatile cyclic imine building blocks for drug discovery and total synthesis programmes.