5-(3-Bromo-phenyl)-7-(6-pyrrolidin-1-yl-pyridin-3-yl)-pyrido[2,3-d]pyrimidin-4-ylamine | 214697-28-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-(3-Bromo-phenyl)-7-(6-pyrrolidin-1-yl-pyridin-3-yl)-pyrido[2,3-d]pyrimidin-4-ylamine
• 英文别名: 5-(3-bromophenyl)-7-(6-pyrrolidin-1-ylpyridin-3-yl)pyrido[2,3-d]pyrimidin-4-amine
• CAS: 214697-28-6
• 化学式: C₂₂H₁₉BrN₆
• 分子量: 447.337
• InChiKey: UFGPDCMTYBWKFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  80.8
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-氯-5-乙酰基吡啶 在 tris formamide 、 ammonium acetate 作用下， 以 乙醇 、 1,2-二氯乙烷 为溶剂， 生成 5-(3-Bromo-phenyl)-7-(6-pyrrolidin-1-yl-pyridin-3-yl)-pyrido[2,3-d]pyrimidin-4-ylamine
  参考文献：
  名称：

  Pyridopyrimidine analogues as novel adenosine kinase inhibitors

  摘要：

  A novel series of pyridopyrimidine analogues 9 was identified as potent adenosine kinase inhibitors based on the SAR and computational studies. Substitution of the C7 position of the pyridopyrimidino core with C2 ' substituted pyridino moiety increased the in vivo potency and enhanced oral bioavailability of these adenosine kinase inhibitors. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00375-4

文献信息

• BETA-CELL REPLICATION PROMOTING COMPOUNDS AND METHODS OF THEIR USE
  申请人：President and Fellows of Harvard College

  公开号：EP2513298A2

  公开（公告）日：2012-10-24
• [EN] BETA-CELL REPLICATION PROMOTING COMPOUNDS AND METHODS OF THEIR USE<br/>[FR] COMPOSÉS PROMOUVANT LA RÉPLICATION DES CELLULES BÊTA ET MÉTHODES D'UTILISATION DE CES COMPOSÉS
  申请人：HARVARD COLLEGE

  公开号：WO2011075665A2

  公开（公告）日：2011-06-23

  In the invention provides for a method of stimulating or increasing β-cell replication or growth, by contacting a β-cell with an inhibitor of adenosine kinase (ADK), an inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) or an activator of AMP activated protein kinase (AMPK).
• Pyridopyrimidine analogues as novel adenosine kinase inhibitors
  作者：Guo Zhu Zheng、Chih-Hung Lee、John K Pratt、Richard J Perner、Mei Qun Jiang、Arthur Gomtsyan、Mark A Matulenko、Yui Mao、John R Koenig、Ki H Kim、Steve Muchmore、Haixia Yu、Kathy Kohlhaas、Karen M Alexander、Steve McGaraughty、Katharine L Chu、Carol T Wismer、Joseph Mikusa、Michael F Jarvis、Kennan Marsh、Elizabeth A Kowaluk、Shripad S Bhagwat、Andrew O Stewart

  DOI：10.1016/s0960-894x(01)00375-4

  日期：2001.8

  A novel series of pyridopyrimidine analogues 9 was identified as potent adenosine kinase inhibitors based on the SAR and computational studies. Substitution of the C7 position of the pyridopyrimidino core with C2 ' substituted pyridino moiety increased the in vivo potency and enhanced oral bioavailability of these adenosine kinase inhibitors. (C) 2001 Elsevier Science Ltd. All rights reserved.