[(2-bromo-4-{[(3,4-dichloro-phenyl)-(5-{3-[3-(1H-tetrazol-5-yl)-phenoxy]-phenyl}-[1,3,4]thiadiazol-2-yl)-amino]-methyl}-phenyl)-difluoro-methyl]-phosphonic acid | 879446-00-1

• 分子结构分类: 有机化合物
• 英文名称: [(2-bromo-4-{[(3,4-dichloro-phenyl)-(5-{3-[3-(1H-tetrazol-5-yl)-phenoxy]-phenyl}-[1,3,4]thiadiazol-2-yl)-amino]-methyl}-phenyl)-difluoro-methyl]-phosphonic acid
• 英文别名: [[2-bromo-4-[(3,4-dichloro-N-[5-[3-[3-(2H-tetrazol-5-yl)phenoxy]phenyl]-1,3,4-thiadiazol-2-yl]anilino)methyl]phenyl]-difluoromethyl]phosphonic acid
• CAS: 879446-00-1
• 化学式: C₂₉H₁₉BrCl₂F₂N₇O₄PS
• 分子量: 781.361
• InChiKey: DKDJUETWVXTICH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  47
• 可旋转键数：
  10
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  179
• 氢给体数：
  3
• 氢受体数：
  13

文献信息

• [EN] DERIVATIVES OF THIAZOLE AND THIADIAZOLE INHIBITORS OF TYROSINE PHOSPHATASES<br/>[FR] DERIVES D'INHIBITEURS DE THIAZOLE ET DE THIADIAZOLE DE TYROSINE PHOSPHATASES
  申请人：CENGENT THERAPEUTICS INC

  公开号：WO2006028970A1

  公开（公告）日：2006-03-16

  Provided herein are compounds and compositions for modulation of tyrosine phosphatase activity. In one embodiment, compounds and compositions for inhibiting protein tyrosine phosphatase activity are provided. In another embodiment, provided herein are compounds and compositions that are useful in the treatment, prevention, or amelioration of one or more symptoms of diseases caused by dysfunctional signal transduction, or in which dysfunctional signal transduction is implicated. In another embodiment, provided herein are compounds and compositions for treatment, prevention, or amelioration of one or more symptoms of diabetes. The compounds have following formulas: (II), (I), (III), and (IV).

  提供了一种用于调节酪氨酸磷酸酶活性的化合物和组合物。在一个实施例中，提供了用于抑制蛋白酪氨酸磷酸酶活性的化合物和组合物。在另一个实施例中，提供了用于治疗、预防或改善由信号转导功能障碍引起的一种或多种症状的疾病，或其中信号转导功能障碍涉及的疾病。在另一个实施例中，提供了用于治疗、预防或改善糖尿病的一种或多种症状的化合物和组合物。这些化合物的公式如下：(II)，(I)，(III)和(IV)。
• Thiazole and thiadiazole inhibitors of tyrosine phosphatases
  申请人：Cheruvallath S. Zacharia

  公开号：US20060194768A1

  公开（公告）日：2006-08-31

  Compounds and compositions are provided for modulating the activity of protein tyrosine phosphatases. In one embodiment, the compounds and compositions are thiazoles and thiadiazoles that inhibit the activity of protein tyrosine phosphatase 1B.

  本发明提供了用于调节蛋白酪氨酸磷酸酶活性的化合物和组合物。在一种实施方式中，所述化合物和组合物是噻唑和噻二唑，可抑制蛋白酪氨酸磷酸酶1B的活性。
• THIAZOLE AND THIADIAZOLE INHIBITORS OF TYROSINE PHOSPHATASES
  申请人：CHERUVALLATH Zacharia S.

  公开号：US20080200371A1

  公开（公告）日：2008-08-21

  Compounds and compositions are provided for modulating the activity of protein tyrosine phosphatases. In one embodiment, the compounds and compositions are thiazoles and thiadiazoles that inhibit the activity of protein tyrosine phosphatase 1B.

  提供了用于调节蛋白酪氨酸磷酸酶活性的化合物和组合物。在一种实施例中，这些化合物和组合物是噻唑和噻二唑，可以抑制蛋白酪氨酸磷酸酶1B的活性。
• DERIVATIVES OF THIAZOLE AND THIADIAZOLE INHIBITORS OF TYROSINE PHOSPHATASES
  申请人：Metabasis Therapeutics, Inc.

  公开号：EP1841749A1

  公开（公告）日：2007-10-10
• US7381736B2
  申请人：——

  公开号：US7381736B2

  公开（公告）日：2008-06-03