2-[2-pyridyl-(methyl)methylsulfinyl]-(5-ethyl)benzimidazole | 60524-94-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-[2-pyridyl-(methyl)methylsulfinyl]-(5-ethyl)benzimidazole
• 英文别名: 6-ethyl-2-(1-pyridin-2-ylethylsulfinyl)-1H-benzimidazole
• CAS: 60524-94-9
• 化学式: C₁₆H₁₇N₃OS
• 分子量: 299.396
• InChiKey: GIJDLNVCIPUWFT-UHFFFAOYSA-N

物化性质

• 沸点：
  540.0±52.0 °C(Predicted)
• 密度：
  1.32±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  77.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Benzimidazoles and their pharmaceutical use
  申请人：THE UPJOHN COMPANY

  公开号：EP0045200A1

  公开（公告）日：1982-02-03

  Substituted alkylsulfinylbenzimidazoles for use as pharmaceuticals or as active ingredients in pharmaceutical compositions, especially of the formula wherein R1, R2, R3 and -X1-Het are defined as given in the description. The compounds are used in the treatment or prevention of special gastrointestinal inflammatory diseases.

  用作药物或药物组合物活性成分的取代烷基亚磺酰基苯并咪唑，特别是以下式子 其中 R1、R2、R3 和 -X1-Het 的定义如描述中所给。这些化合物可用于治疗或预防特殊的胃肠道炎症疾病。
• COMBINATION OF CRTH2 ANTAGONIST AND A PROTON PUMP INHIBITOR FOR THE TREATMENT OF EOSINOPHILIC ESOPHAGITIS
  申请人：Atopix Therapeutics Limited

  公开号：EP2790696A1

  公开（公告）日：2014-10-22
• Combination of CRTH2 Antagonist and a Proton Pump Inhibitor for the Treatment of Eosinophilic Esophagitis
  申请人：Atopix Therapeutics Limited

  公开号：US20140328861A1

  公开（公告）日：2014-11-06

  Disclosed are methods and compositions for preventing, treating, or ameliorating eosinophilic esophagitis (EoE) in an individual, comprising administering to the individual a therapeutically effective amount of at least one CRTH2 antagonist or a pharmaceutically acceptable salt thereof and at least one proton pump inhibitor (PPI) or a pharmaceutically acceptable salt thereof. Also disclosed are compositions comprising at least one CRTH2 antagonist or a pharmaceutically acceptable salt thereof and at least one proton pump inhibitor or a pharmaceutically acceptable salt thereof.
• US4045563A
  申请人：——

  公开号：US4045563A

  公开（公告）日：1977-08-30
• US4359465A
  申请人：——

  公开号：US4359465A

  公开（公告）日：1982-11-16