2,4-bis-n-propyl-4,9-dihydro-5-n-propyloxy-2,4,7,9-tetraazafluorene-1,3-dione | 1174656-92-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并嘧啶类
• 英文名称: 2,4-bis-n-propyl-4,9-dihydro-5-n-propyloxy-2,4,7,9-tetraazafluorene-1,3-dione
• 英文别名: 13-Propoxy-3,5-dipropyl-3,5,8,11-tetrazatricyclo[7.4.0.02,7]trideca-1(13),2(7),9,11-tetraene-4,6-dione
• CAS: 1174656-92-8
• 化学式: C₁₈H₂₄N₄O₃
• 分子量: 344.414
• InChiKey: LMDJIXVWEXHGAT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  78.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1,3-bis-n-propyl-5-(5-n-propyloxypyridin-3-ylamino)uracil 以 甲苯 为溶剂， 反应 10.0h， 以14%的产率得到2,4-bis-n-propyl-4,9-dihydro-5-n-propyloxy-2,4,7,9-tetraazafluorene-1,3-dione
  参考文献：
  名称：

  Synthesis of hybrid analogues of caffeine and eudistomin D and its affinity for adenosine receptors

  摘要：

  Four bis-N-n-propyl analogues (3-6) in the uracil ring of two hybrid molecules (1 and 2) of caffeine and eudistomin D, a beta-carboline alkaloid from a marine tunicate, were synthesized, and their affinity and selectivity for adenosine receptors A(1), A(2A), and A(3) were examined. All the compounds (3-6) showed better potency as adenosine receptor ligands than caffeine. Bis-N-n-propylation (3 and 4, respectively) of the uracil ring in 1 and 2 resulted in higher affinity for A(1) and A(2A) adenosine receptors. Furthermore, it was found that a compound (5) possessing a n-propyloxy group at C-7 in compound 3 with a nitrogen at the beta-position of the pyridine ring (beta-N type) enhanced remarkably affinity for adenosine receptor A3 subtype, while n-propyloxy substitution (compound 6) at C-5 in compound 4 with a nitrogen at the delta-position of the pyridine ring (delta-N type) reduced affinity for all the adenosine receptor, A(1), A(2A), and A(3). Among all the compounds (1-6) examined, compound 5 showed the most potent affinity for adenosine receptor A(3) subtype (K-i value, 0.00382 mu M). (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.05.036

文献信息

• Synthesis of hybrid analogues of caffeine and eudistomin D and its affinity for adenosine receptors
  作者：Haruaki Ishiyama、Hikaru Nakajima、Hiroyasu Nakata、Jun’ichi Kobayashi

  DOI：10.1016/j.bmc.2009.05.036

  日期：2009.7

  Four bis-N-n-propyl analogues (3-6) in the uracil ring of two hybrid molecules (1 and 2) of caffeine and eudistomin D, a beta-carboline alkaloid from a marine tunicate, were synthesized, and their affinity and selectivity for adenosine receptors A(1), A(2A), and A(3) were examined. All the compounds (3-6) showed better potency as adenosine receptor ligands than caffeine. Bis-N-n-propylation (3 and 4, respectively) of the uracil ring in 1 and 2 resulted in higher affinity for A(1) and A(2A) adenosine receptors. Furthermore, it was found that a compound (5) possessing a n-propyloxy group at C-7 in compound 3 with a nitrogen at the beta-position of the pyridine ring (beta-N type) enhanced remarkably affinity for adenosine receptor A3 subtype, while n-propyloxy substitution (compound 6) at C-5 in compound 4 with a nitrogen at the delta-position of the pyridine ring (delta-N type) reduced affinity for all the adenosine receptor, A(1), A(2A), and A(3). Among all the compounds (1-6) examined, compound 5 showed the most potent affinity for adenosine receptor A(3) subtype (K-i value, 0.00382 mu M). (C) 2009 Elsevier Ltd. All rights reserved.