5-methyl-2-hydroxyacetophenonemethanesulfonylhydrazone | 1163120-54-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 5-methyl-2-hydroxyacetophenonemethanesulfonylhydrazone
• 英文别名: 5mafmsh
• CAS: 1163120-54-4
• 化学式: C₁₀H₁₄N₂O₃S
• 分子量: 242.299
• InChiKey: XSRGCQWSBKSNIS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.97
• 重原子数：
  16.0
• 可旋转键数：
  3.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  78.76
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  六羰基钨 、 5-methyl-2-hydroxyacetophenonemethanesulfonylhydrazone 以 四氢呋喃 为溶剂， 反应 2.0h， 以64%的产率得到[W(CO)₅(5mafmsh)]
  参考文献：
  名称：

  Investigation of Photochemical Reactions of some Metal Carbonyls with N´-(2-Hydroxy-6- Methylbenzylidene)Methanesulfonohydrazide and 5-Methyl- 2-Hydroxyacetophenonemethanesulfonylhydrazone

  摘要：

  Eight new complexes, [M(CO)(5)(5msalmsh)] [M=Cr;(1a), Mo;(2a); W(3a)] , [Re(CO)(4)Br(5msalmsh)] (4a), [M(CO)(5)(5mafmsh)] [M=Cr;(1b), Mo;(2b); W(3b)], [Re(CO)(4)Br(5mafmsh)] (4b), have been synthesized by the photochemical reaction of the metal carbonyls [M(CO)(6)] (M=Cr, Mo, W) and [Re(CO)(5)Br] with N'-(2-Hydroxy-6-Methylbenzylidene) Methanesulfonohydrazide (5msalmsh) and 5-methyl-2-hydroxyacetophenonemethanesulfonylhydrazone (5mafmsh). The complexes have been characterized by elemental analysis, LC-MS, FT-IR, H-1 NMR spectroscopy. Spectroscopic studies show that 5msalmsh and 5mafmsh behave monodentate ligand and coordinate via an imine N donor atom to the central metal atom in (1a)-(4a) and (1b)-(4b).

  DOI：

  10.17344/acsi.2019.5249

文献信息

• 10.17344/acsi.2020.5249
  作者：Sert, Sema

  DOI：10.17344/acsi.2020.5249

  日期：——
• Synthesis, characterization and antibacterial activity of new sulfonamide derivatives and their nickel(II), cobalt(II) complexes
  作者：Ümmühan Ö. Özdemir、Pınar Güvenç、Ertan Şahin、Fatma Hamurcu

  DOI：10.1016/j.ica.2008.11.029

  日期：2009.6

  Methanesulfonicacid hydrazide (a sulfonamide compound, msh: CH3SO2NHNH2) derivatives: methylsalicylaldehydemethanesulfonylhydrazone (5msalmsh), 5-methyl-2-hydroxyaceto-phenonemethane-sulfonylhydrazone (5mafmsh) and their Ni(II), Co(II) complexes have been synthesized for the first time. The structure of these sulfonamide compounds has been investigated by using elemental analyses; FT-IR, H-1 NMR, C-13 NMR, LC-MS, and UV-Vis spectrometric methods; magnetic susceptibility; conductivity measurements; thermal studies. The crystal structure of 5msalmsh has been investigated by X-ray analysis. The antibacterial activities of synthesized compounds were studied against gram positive bacteria: Staphylococcus aureus, Bacillus subtilis, and Bacillus magaterium; and gram negative bacteria: Salmonella enteritidis, and Escherichia coli by using the microdilution broth method. The biological activity screening showed that ligands have more activity than complexes against the tested bacteria. (C) 2008 Elsevier B.V. All rights reserved.