4-Hydrazino-6-methyl-2-ethyl-pyrimidin | 90000-46-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-Hydrazino-6-methyl-2-ethyl-pyrimidin
• 英文别名: (2-Ethyl-6-methylpyrimidin-4-yl)hydrazine
• CAS: 90000-46-7
• 化学式: C₇H₁₂N₄
• 分子量: 152.199
• InChiKey: HLWCKMMTVAGECQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  63.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• HYDRAZIDE CONTAINING NUCLEAR TRANSPORT MODULATORS AND USES THEREOF
  申请人：Karyopharm Therapeutics Inc.

  公开号：US20190330164A1

  公开（公告）日：2019-10-31

  The invention generally relates to nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to a compound represented by structural formula I: or a pharmaceutically acceptable salt thereof, wherein the values and alternative values for the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity.