(6-{(pyridin-2-ylsulfonyl)[4-(pyrimidin-2-yl)benzyl]aminomethyl}pyridin-2-ylamino)-acetic acid hydrochloride | 1187450-93-6

• 分子结构分类: 有机化合物
• 英文名称: (6-{(pyridin-2-ylsulfonyl)[4-(pyrimidin-2-yl)benzyl]aminomethyl}pyridin-2-ylamino)-acetic acid hydrochloride
• 英文别名: 2-[[6-[[Pyridin-2-ylsulfonyl-[(4-pyrimidin-2-ylphenyl)methyl]amino]methyl]pyridin-2-yl]amino]acetic acid;hydrochloride
• CAS: 1187450-93-6
• 化学式: C₂₄H₂₂N₆O₄S*ClH
• 分子量: 527.003
• InChiKey: NPWYCGSWKWPIJB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.24
• 重原子数：
  36
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  147
• 氢给体数：
  3
• 氢受体数：
  10

文献信息

• PYRIDYLAMINOACETIC ACID COMPOUND
  申请人：UBE INDUSTRIES, LTD.

  公开号：US20140113907A1

  公开（公告）日：2014-04-24

  The present invention provides a pyridylaminoacetic acid compound represented by the following formula (1): (wherein R 1 , R 2 , R 3 , Y and Z are as defined in the description and claims), or a pharmacologically acceptable salt thereof. Since the pyridylaminoacetic acid compound has EP2 agonistic action, it is useful as a therapeutic or prophylactic drug for respiratory diseases such as asthma or chronic obstructive pulmonary disease.

  本发明提供了一种由以下式(1)表示的吡啶基氨基乙酸化合物：(其中R1、R2、R3、Y和Z如说明和权利要求中所定义)，或其药学上可接受的盐。由于该吡啶基氨基乙酸化合物具有EP2激动作用，因此它可用作治疗或预防哮喘或慢性阻塞性肺疾病等呼吸系统疾病的药物。
• MEDICAL COMPOSITION FOR TREATMENT OR PROPHYLAXIS OF GLAUCOMA
  申请人：Hagihara Masahiko

  公开号：US20120190852A1

  公开（公告）日：2012-07-26

  The present invention is to provide a medical composition for the treatment or prophylaxis of glaucoma which comprises a pyridylaminoacetic acid compound represented by the formula (1): wherein R 1 , R 2 and R 3 each independently represent a hydrogen atom or C 1 -C 6 alkyl group, Y represents a bicyclic heteroaromatic ring group which may be substituted by a group(s) selected from the group consisting of a halogen atom, C 1 -C 6 alkyl group, halogeno C 1 -C 6 alkyl group, C 1 -C 6 alkoxyl group, halogeno C 1 -C 6 alkoxyl group and C 1 -C 6 alkylthio group or a group -Q 1 -Q 2 wherein Q 1 represents an arylene group or 5- to 6-membered heteroarylene group, Q 2 represents an aromatic group or a 5- to 6-membered ring heterocyclic group each of which may be substituted by a group(s) selected from the group consisting of a halogen atom, hydroxyl group, C 1 -C 6 alkyl group, halogeno C 1 -C 6 alkyl group, C 1 -C 6 alkoxyl group and halogeno C 1 -C 6 alkoxyl group, Z represents an aromatic group or a 5- to 6-membered heteroaromatic ring group each of which may be substituted by a group(s) selected from the group consisting of a halogen atom, C 1 -C 6 alkyl group, halogeno C 1 -C 6 alkyl group, C 1 -C 6 alkoxyl group and halogeno C 1 -C 6 alkoxyl group, or a pharmaceutically acceptable salt thereof as an effective ingredient.

  本发明提供了一种用于治疗或预防青光眼的医用组合物，该组合物包括以下式子（1）所表示的吡啶基氨基乙酸化合物：其中，R1、R2和R3各自独立地表示氢原子或C1-C6烷基；Y表示一个双环杂芳基环基，该环基可以被选自卤素原子、C1-C6烷基、卤代C1-C6烷基、C1-C6烷氧基、卤代C1-C6烷氧基和C1-C6烷基硫基或-Q1-Q2基团所取代；其中，Q1表示芳烃基或5-至6-成员杂芳烃基，Q2表示芳香基或5-至6-成员环杂芳基，每个基团都可以被选自卤素原子、羟基、C1-C6烷基、卤代C1-C6烷基、C1-C6烷氧基和卤代C1-C6烷氧基的基团所取代；Z表示芳香基或5-至6-成员杂芳基环基，每个基团都可以被选自卤素原子、C1-C6烷基、卤代C1-C6烷基、C1-C6烷氧基和卤代C1-C6烷氧基的基团所取代，或其药学上可接受的盐作为有效成分。
• PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING GLAUCOMA
  申请人：Ube Industries, Ltd.

  公开号：EP2415763B1

  公开（公告）日：2016-01-27
• US8648097B2
  申请人：——

  公开号：US8648097B2

  公开（公告）日：2014-02-11