5-{4-[2-(2-amino-1-methyl-1H-imidazol-4-yl)-2-(4-methoxyphenyl)ethyl]phenyl}pyridin-2-ol | 1186101-68-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 5-{4-[2-(2-amino-1-methyl-1H-imidazol-4-yl)-2-(4-methoxyphenyl)ethyl]phenyl}pyridin-2-ol
• 英文别名: 5-[4-[2-(2-amino-1-methylimidazol-4-yl)-2-(4-methoxyphenyl)ethyl]phenyl]-1H-pyridin-2-one
• CAS: 1186101-68-7
• 化学式: C₂₄H₂₄N₄O₂
• 分子量: 400.48
• InChiKey: CGSKUTVDJXNMIB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  82.2
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] 2-AMINOIMIDAZOLE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE<br/>[FR] INHIBITEURS DE LA 2-AMINOIMIDAZOLE BÊTA-SECRÉTASE UTILES POUR LE TRAITEMENT DE LA MALADIE D'ALZHEIMER
  申请人：MERCK & CO INC

  公开号：WO2009108550A1

  公开（公告）日：2009-09-03

  The present invention is directed to 2-aminoimidazole compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

  本发明涉及式(I)的2-氨基咪唑化合物，它们是β-分泌酶酶的抑制剂，可用于治疗涉及β-分泌酶酶的疾病，如阿尔茨海默病。该发明还涉及包含这些化合物的药物组合物，以及在治疗涉及β-分泌酶酶的疾病中使用这些化合物和组合物。
• 2-AMINOIMIDAZOLE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
  申请人：Hills Ivory D.

  公开号：US20110034483A1

  公开（公告）日：2011-02-10

  The present invention is directed to 2-aminoimidazole compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

  本发明涉及式(I)的2-氨基咪唑化合物，它们是β-分泌酶酶的抑制剂，并且在治疗β-分泌酶酶参与的疾病，如阿尔茨海默病中有用。该发明还涉及包含这些化合物的制药组合物以及这些化合物和组合物在治疗β-分泌酶酶参与的这种疾病中的用途。
• US8492387B2
  申请人：——

  公开号：US8492387B2

  公开（公告）日：2013-07-23