3-(bromomethyl)-3-methyloxolane | 15833-76-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢呋喃
• 英文名称: 3-(bromomethyl)-3-methyloxolane
• CAS: 15833-76-8
• 化学式: C₆H₁₁BrO
• 分子量: 179.057
• InChiKey: XPQOXNXJHMCUCI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• IMIDAZO[1,2-A]PYRIDINYL DERIVATIVES AS IRAK4 INHIBITORS
  申请人：BIOGEN MA INC.

  公开号：US20220089592A1

  公开（公告）日：2022-03-24

  This invention relates to Imidazo[1,2-a]pyridinyl Derivatives of formula (I′), or pharmaceutically acceptable salts thereof, in which all of the variables are as defined in the specification, capable of modulating the activity of IRAK4. The invention further provides a method of manufacturing compounds of the invention, and methods for their therapeutic use. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including inflammatory disease, autoimmune disease, cancer, cardiovascular disease, a disease of the central nervous system, disease of the skin, an ophthalmic disease and condition, and a bone disease.

  这项发明涉及Imidazo[1,2-a]pyridinyl Derivatives的化合物（I′）或其药学上可接受的盐，其中所有变量如规范中所定义，能够调节IRAK4的活性。该发明进一步提供了一种制造该发明化合物的方法，以及它们在治疗中的方法。该发明还提供了它们的制备方法，医学用途，特别是在治疗和管理炎症性疾病、自身免疫疾病、癌症、心血管疾病、中枢神经系统疾病、皮肤疾病、眼科疾病和骨骼疾病等疾病或疾病的用途。
• [EN] COPOLYMER POLYCARBONATE HAVING SELF-REPAIRING FUNCTION AND PREPARATION METHOD THEREFOR<br/>[FR] POLYCARBONATE COPOLYMÈRE AYANT UNE FONCTION D'AUTO-RÉPARATION ET SON PROCÉDÉ DE PRÉPARATION<br/>[ZH] 具有自修复功能的共聚聚碳酸酯及其制备方法
  申请人：PEKING PUYUAN INSTITUTE FOR ADVANCED MATERIALS AND TECH

  公开号：WO2020192381A1

  公开（公告）日：2020-10-01

  本发明涉及一种具有自修复功能的共聚聚碳酸酯及其制备方法，所述方法包括如下步骤：首先将还原性糖、氧杂环丁烷衍生物和第一催化剂混合后加热到50℃～80℃，搅拌反应0.5h～2h，得到第一产物；向第一产物中加入二元醇、二元酯和第二催化剂，然后加热至180℃～220℃保温反应2h～4h，得到低聚物；将低聚物加热至230℃～270℃并保温反应1h～3h，得到具有自修复功能的共聚聚碳酸酯。本发明的方法制备的自修复共聚聚碳酸酯材料具有自修复性和可生物降解性，保证了产品的一致性和均匀性。另外，引入主链的嵌段绿色环保，未改变聚碳酸酯清洁生产的初衷。
• [EN] IMIDAZO[1,2-A]PYRIDINYL DERIVATIVES AS IRAK4 INHIBITORS<br/>[FR] DÉRIVÉS D'IMIDAZO[1,2-A]PYRIDINYLE SERVANT D'INHIBITEURS D'IRAK4
  申请人：BIOGEN MA INC

  公开号：WO2020150626A1

  公开（公告）日：2020-07-23

  This invention relates to Imidazo[1,2-a]pyridinyl Derivatives of formula (I'), or pharmaceutically acceptable salts thereof, in which all of the variables are as defined in the specification, capable of modulating the activity of IRAK4. The invention further provides a method of manufacturing compounds of the invention, and methods for their therapeutic use. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including inflammatory disease, autoimmune disease, cancer, cardiovascular disease, a disease of the central nervous system, disease of the skin, an ophthalmic disease and condition, and a bone disease.