4-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)benzaldehyde | 1293912-51-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 4-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)benzaldehyde
• CAS: 1293912-51-2
• 化学式: C₁₉H₁₁NO₃
• 分子量: 301.301
• InChiKey: WUARGTHNXFPPRM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.45
• 重原子数：
  23.0
• 可旋转键数：
  2.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.45
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  4-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)benzaldehyde 、 1-硫代-b-D-吡喃葡萄糖苷对甲苯酯 在 对甲苯磺酸一水合物 作用下， 以 N,N-二甲基甲酰胺 、 苯 为溶剂， 反应 4.0h， 以80%的产率得到2-[4-[(2R,4aR,6S,7R,8R,8aS)-7,8-dihydroxy-6-phenylsulfanyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-2-yl]phenyl]benzo[de]isoquinoline-1,3-dione
  参考文献：
  名称：

  Preparation of tagged glucose as a key intermediate in the synthesis of branched oligosaccharides

  摘要：

  Tagged and activated D-glucose was introduced as a building block for branched oligosaccharides. This building block was the oligosaccharide branching point at which selectively the C-2 followed by the C-3 position can be glycosylated. After the activation of the C-1 position by oxidation of a thiophenyl group, the newly formed tagged oligosaccharide can be used as a glycoside donor. Synthetic procedures for the preparation of phthalimide-based tag molecules as well as tagged monosaccharides are presented. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.01.149
• 作为产物：
  描述：

  乙烷,三氯氟- 在 吡啶 、 N-溴代丁二酰亚胺(NBS) 、 水 作用下， 以 苯 为溶剂， 反应 2.0h， 生成 4-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)benzaldehyde
  参考文献：
  名称：

  Preparation of tagged glucose as a key intermediate in the synthesis of branched oligosaccharides

  摘要：

  Tagged and activated D-glucose was introduced as a building block for branched oligosaccharides. This building block was the oligosaccharide branching point at which selectively the C-2 followed by the C-3 position can be glycosylated. After the activation of the C-1 position by oxidation of a thiophenyl group, the newly formed tagged oligosaccharide can be used as a glycoside donor. Synthetic procedures for the preparation of phthalimide-based tag molecules as well as tagged monosaccharides are presented. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.01.149