3-methyl-6-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-pyridazine | 1174674-58-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 3-methyl-6-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-pyridazine
• 英文别名: 3-methyl-6-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]pyridazine
• CAS: 1174674-58-8
• 化学式: C₁₉H₂₅N₃O
• 分子量: 311.427
• InChiKey: ZCYMPPUULSIWCT-MRXNPFEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  38.2
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] SUBSTITUTED PYRIDAZINE DERIVATIVES WHICH HAVE HISTAMINE H3 ANTAGONIST ACTIVITY<br/>[FR] DÉRIVÉS DE PYRIDAZINE SUBSTITUÉS À ACTIVITÉ ANTAGONISTE DES RÉCEPTEURS H3 DE L'HISTAMINE
  申请人：CEPHALON INC

  公开号：WO2009097306A1

  公开（公告）日：2009-08-06

  The present invention is directed to compounds having histamine H3 antagonist activity, as well as methods of their use and preparation.

  本发明涉及具有组胺H3拮抗活性的化合物，以及它们的使用和制备方法。
• Substituted Pyridazine Derivatives
  申请人：Hudkins Robert L.

  公开号：US20120004231A1

  公开（公告）日：2012-01-05

  The present invention is directed to compounds having histamine H 3 antagonist activity, as well as methods of their use and preparation.

  本发明涉及具有组胺H3拮抗活性的化合物，以及它们的使用和制备方法。
• Substituted pyridazine derivatives
  申请人：Hudkins Robert L.

  公开号：US20100311752A1

  公开（公告）日：2010-12-09

  The present invention is directed to compounds having histamine H 3 antagonist activity, as well as methods of their use and preparation.

  本发明涉及具有组胺H3受体拮抗活性的化合物，以及它们的使用和制备方法。
• Substituted pyridazine derivatives which have histamine H3 antagonist activity
  申请人：CEPHALON, INC.

  公开号：EP2752406A1

  公开（公告）日：2014-07-09

  The present invention is directed to compounds of formula (I) having histamine H3 antagonist activity, as well as methods of their use and preparation. A compound of Formula I:

  本发明涉及具有组胺 H3 拮抗剂活性的式 (I) 化合物及其使用和制备方法。 式 I 的化合物
• SUBSTITUTED PYRIDAZINE DERIVATIVES WHICH HAVE HISTAMINE H3 ANTAGONIST ACTIVITY
  申请人：Cephalon, Inc.

  公开号：EP2252593A1

  公开（公告）日：2010-11-24