6-(2,6-Dimethylmorpholin-4-yl)pyridine-3-carboxylic acid | 926271-03-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-(2,6-Dimethylmorpholin-4-yl)pyridine-3-carboxylic acid
• CAS: 926271-03-6
• 化学式: C₁₂H₁₆N₂O₃
• mdl: MFCD09047840
• 分子量: 236.27
• InChiKey: ZABGXMCXGREUAJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  62.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• SUBSTITUTED PIPERIDINYLTETRAHYDROQUINOLINES
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US20160304491A1

  公开（公告）日：2016-10-20

  The present application relates to novel substituted piperidinyltetrahydroquinolines, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardial vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.

  本申请涉及新型取代哌啶基四氢喹啉，其制备方法，其用于治疗和/或预防疾病以及用于制备治疗和/或预防疾病的药物，特别是用于治疗和/或预防糖尿病微血管病变、四肢糖尿病溃疡，特别是促进糖尿病足溃疡伤口愈合，糖尿病心力衰竭，糖尿病冠脉微血管心脏疾病，周围和心脏血管疾病，血栓栓塞性疾病和缺血症，周围循环障碍，雷诺现象，CREST综合征，微循环障碍，间歇性跛行以及周围和自主神经病变的治疗和/或预防。
• [EN] TOPICAL PHARMACEUTICAL COMPOSITION INCLUDING REL-N- [6 - [ (2R, 6S) - 2, 6 - DIMETHYL - 4 -MORPHOLINYL] -3 - PYRIDINYL] - 2 -METHYL -41 (TRIFLUOROMETHOXY) - [1,1' -BIPHENYL] - 3 - CARBOXAMIDE<br/>[FR] COMPOSITIONS PHARMACEUTIQUES
  申请人：NOVARTIS AG

  公开号：WO2011009852A3

  公开（公告）日：2012-01-19
• TOPICAL PHARMACEUTICAL COMPOSITION INCLUDING REL-N-[6-[(2R,6S)-2,6-DIMETHYL-4-MORPHOLINYL]-3-PYRIDINYL]-2-METHYL-41-(TRIFLUOROMETHOXY)-[1,1'-BIPHENYL]-3-CARBOXAMIDE.
  申请人：Novartis AG

  公开号：EP2456422A2

  公开（公告）日：2012-05-30
• SUBSTITUIERTE PIPERIDINYL-TETRAHYDROCHINOLINE
  申请人：Bayer Pharma Aktiengesellschaft

  公开号：EP3083593A1

  公开（公告）日：2016-10-26
• US9624198B2
  申请人：——

  公开号：US9624198B2

  公开（公告）日：2017-04-18