N-[4-(benzimidazol-1-yl)-2-(4-toluenesulfonylamino)-phenyl]-4-toluenesulfonamide | 872870-29-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: N-[4-(benzimidazol-1-yl)-2-(4-toluenesulfonylamino)-phenyl]-4-toluenesulfonamide
• 英文别名: N-[4-(benzimidazol-1-yl)-2-[(4-methylphenyl)sulfonylamino]phenyl]-4-methylbenzenesulfonamide
• CAS: 872870-29-6
• 化学式: C₂₇H₂₄N₄O₄S₂
• 分子量: 532.644
• InChiKey: ZTONPOBPQUASKQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  37
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  127
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Sulfonamide-based compounds as protein tyrosine kinase inhibitors
  申请人：Thrash Thomas

  公开号：US20060004197A1

  公开（公告）日：2006-01-05

  Various sulfonamide-based compounds are able to selectively inhibit the Src family of tyrosine kinases. These compounds are useful in the treatment of various diseases including hyperproliferative diseases, hematologic diseases, osteoporosis, neurological diseases, autoimmune diseases, allergic/immunological diseases, or viral infections.

  各种基于磺胺的化合物能够选择性地抑制Src家族的酪氨酸激酶。这些化合物在治疗各种疾病中很有用，包括高增殖性疾病、血液学疾病、骨质疏松症、神经系统疾病、自身免疫疾病、过敏/免疫疾病或病毒感染。
• [EN] SULFONAMIDE-BASED COMPOUNDS AS PROTEIN TYROSINE KINASE INHIBITORS<br/>[FR] COMPOSES A BASE DE SULFONAMIDE EN TANT QU'INHIBITEURS DE PROTEINE TYROSINE KINASE
  申请人：SIGNASE INC

  公开号：WO2006014405A2

  公开（公告）日：2006-02-09

  Various sulfonamide-based compounds are able to selectively inhibit the Src family of tyrosine kinases. These compounds are useful in the treatment of various diseases including hyperproliferative diseases, hematologic diseases, osteoporosis, neurological diseases, autoimmune diseases, allergic/irnmunological diseases, or viral infections.