Bis(2-acetyloxycarbonylphenyl) hexanedioate | 851546-58-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Bis(2-acetyloxycarbonylphenyl) hexanedioate
• CAS: 851546-58-2
• 化学式: C₂₄H₂₂O₁₀
• 分子量: 470.433
• InChiKey: DBRQMXPRGJTLQB-UHFFFAOYSA-N

物化性质

• 沸点：
  658.4±55.0 °C(Predicted)
• 密度：
  1.300±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  34
• 可旋转键数：
  15
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  139
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  己二酰氯 在 吡啶 作用下， 以 四氢呋喃 为溶剂， 生成 Bis(2-acetyloxycarbonylphenyl) hexanedioate
  参考文献：
  名称：

  Effect of Linker Structure on Salicylic Acid-Derived Poly(anhydride−esters)

  摘要：

  A series of salicylic acid-derived poly(anhydride -esters) were synthesized by melt polymerization methods, in which the structures of the molecule ("linker") linking together the two salicylic acids were varied. To determine the relationship between the linker and the physical properties of the corresponding poly(anhydride-ester), several linkers were evaluated including linear aliphatic, aromatic, and aliphatic branched structures. For the linear aliphatic linkers, higher molecular weights were obtained with longer linear alkyl chains. The most sterically hindered linkers yielded lower molecular weight polymers. The thermal decomposition temperature increased with the alkyl chain length, but the glass transition temperature decreased, due to the enhanced flexibility of the polymer. The highest glass transition temperatures were obtained by using aromatic linkers as a result of inereased pi-pi interactions. Water contact angles determined the relative hydrophobicity of the polymers, which correlated to hydrolytic degradation rates; i.e., the highest contact angle values yielded the slowest degrading polymers.

  DOI：

  10.1021/ma048051u

文献信息

• PROCESS AND INTERMEDIATES FOR PREPARING POLY(ANHYDRIDE-ESTERS)
  申请人：Rutgers, the State University of New Jersey

  公开号：US20170121267A1

  公开（公告）日：2017-05-04

  Certain embodiments of the invention provide a method comprising treating a hydroxy-carboxylic acid compound with a compound of formula (I) in the absence of a solvent, to provide a diacid of formula (II), wherein R is a linker molecule; wherein each Y is independently a leaving group; and wherein X is a residue of a biologically active compound.

  本发明的某些实施例提供了一种方法，包括在无溶剂的情况下用式(I)的化合物处理羟基羧酸化合物，以提供式(II)的二酸，其中R是一个连接分子，其中每个Y是独立的离去基，X是生物活性化合物的残基。
• Iodinated polymers
  申请人：Uhrich Kathryn E.

  公开号：US08361453B2

  公开（公告）日：2013-01-29

  The invention provides medical devices that comprise an iodinated polymer and that can be viewed using X-Ray imaging techniques. The invention also provides novel iodinated polymers that can be incorporated into or coated on medical devices.

  这项发明提供了包含碘化聚合物的医疗器械，可以使用X射线成像技术进行观察。该发明还提供了可以用于医疗器械中的新型碘化聚合物，可以被纳入或涂覆在医疗器械上。
• Process and intermediates for preparing poly(anhydride-esters)
  申请人：Rutgers, the State University of New Jersey

  公开号：US10023521B2

  公开（公告）日：2018-07-17

  Certain embodiments of the invention provide a method comprising treating a hydroxy-carboxylic acid compound with a compound of formula (I) in the absence of a solvent, to provide a diacid of formula (II), wherein R is a linker molecule; wherein each Y is independently a leaving group; and wherein X is a residue of a biologically active compound.

  本发明的某些实施方案提供了一种方法，该方法包括在无溶剂的情况下，用式（I）化合物处理羟基羧酸化合物，以提供式（II）的二元酸，其中 R 是连接分子；其中每个 Y 独立地是离去基团；其中 X 是生物活性化合物的残基。