[5-(2-Methoxy-pyrimidin-5-yl)-benzooxazol-2-yl]-phenyl-amine | 1220280-37-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: [5-(2-Methoxy-pyrimidin-5-yl)-benzooxazol-2-yl]-phenyl-amine
• 英文别名: 5-(2-methoxypyrimidin-5-yl)-N-phenyl-1,3-benzoxazol-2-amine
• CAS: 1220280-37-4
• 化学式: C₁₈H₁₄N₄O₂
• 分子量: 318.335
• InChiKey: BDHMAHUYKNTGTO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  73.1
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] COMPOUNDS USEFUL AS FAAH MODULATORS AND USES THEREOF<br/>[FR] COMPOSÉS UTILES EN TANT QUE MODULATEURS DE LA FAAH ET LEURS UTILISATIONS
  申请人：RENOVIS INC

  公开号：WO2010039186A2

  公开（公告）日：2010-04-08

  Compounds are disclosed that have formula I: wherein X, R1, R2, R3, R4 and n are as defined herein. The compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, anxiety, depression, inflammation, cognitive disorders, weight and eating disorders, Parkinson's disease, Alzheimer's disease, spasticity, addiction, glaucoma, and others.