1-(2,2-dimethyl-propionyloxy)-5-methyl-pyrrolidin-2-one | 60769-70-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-(2,2-dimethyl-propionyloxy)-5-methyl-pyrrolidin-2-one
• 英文别名: (2-Methyl-5-oxopyrrolidin-1-yl) 2,2-dimethylpropanoate
• CAS: 60769-70-2
• 化学式: C₁₀H₁₇NO₃
• 分子量: 199.25
• InChiKey: QLIZUNUYXGRIQO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-Hydroxy-5-methylpyrrolidin-2-one 、 三甲基乙酰氯 以82%的产率得到
  参考文献：
  名称：

  BELLASIO E.; CAVALLERI B.; LA NOCE T.; TESTA E., FARMACO ED. SCI. , 1976, 31, NO 7, 471-477

  摘要：

  DOI：

文献信息

• Cytotoxic peptides and conjugates thereof
  申请人：NOVARTIS AG

  公开号：US10280139B2

  公开（公告）日：2019-05-07

  Disclosed herein are novel compounds of formula (I) as described herein: and the use of such peptides in making immunoconjugates (i.e Antibody Drug Conjugates) Also described herein are immunoconjugates (i.e Antibody Drug Conjugates) comprising such novel compound linked to an antigen binding moiety, such as an antibody; where such immunoconjugates are useful for treating cell proliferative disorders. The invention further provides pharmaceutical compositions comprising these immunoconjugates, compositions comprising the immunoconjugates with a therapeutic co-agent, and methods to use these immunoconjugates and compositions for treating cell proliferation disorders.

  本文公开了如本文所述的新型式 (I) 化合物： 本发明还描述了免疫结合剂（即抗体药物结合剂），其包含与抗原结合分子（如抗体）连接的此类新型化合物；其中此类免疫结合剂可用于治疗细胞增殖性疾病。本发明进一步提供了包含这些免疫共轭物的药物组合物、包含这些免疫共轭物与治疗共用试剂的组合物，以及使用这些免疫共轭物和组合物治疗细胞增殖障碍的方法。
• CYTOTOXIC PEPTIDES AND CONJUGATES THEREOF
  申请人：NOVARTIS AG

  公开号：US20180155281A1

  公开（公告）日：2018-06-07

  Disclosed herein are novel compounds of formula (I) as described herein: and the use of such peptides in making immunoconjugates (i.e Antibody Drug Conjugates) Also described herein are immunoconjugates (i.e Antibody Drug Conjugates) comprising such novel compound linked to an antigen binding moiety, such as an antibody; where such immunoconjugates are useful for treating cell proliferative disorders. The invention further provides pharmaceutical compositions comprising these immunoconjugates, compositions comprising the immunoconjugates with a therapeutic co-agent, and methods to use these immunoconjugates and compositions for treating cell proliferation disorders.
• 3D in vitro Models of Lung Tissue
  申请人：THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

  公开号：US20200347359A1

  公开（公告）日：2020-11-05

  The invention relates to the discovery of tissue mimicking constructs and compositions that can be used to study the growth and development of cells in vitro. In certain embodiments, the invention provides methods of culturing cells on the tissue mimicking polymer microspheres. In other embodiments, the invention provides methods of treating a disease or disorder using the compositions and constructs of the invention.
• US9988420B2
  申请人：——

  公开号：US9988420B2

  公开（公告）日：2018-06-05