1-Aminomethyl-1-cyclohexan-essigsaeure | 64924-38-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-Aminomethyl-1-cyclohexan-essigsaeure
• 英文别名: 2-[1-(Aminomethyl)cyclohexyl]acetic acid;benzenesulfonic acid
• CAS: 64924-38-5
• 化学式: C₆H₆O₃S*C₉H₁₇NO₂
• 分子量: 329.417
• InChiKey: BBZPPPNVZUVGSW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  126
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Process for the preparation of amino methyl cyclo alkane acetic acids
  申请人：Kuppuswamy Nagarajan

  公开号：US20060149099A1

  公开（公告）日：2006-07-06

  This invention relates to an improved process for the preparation of amino methyl cyclo alkane acetic acids. This invention particularly relates to an improved process for the preparation of gabapentin (which is chemically known as 1-aminomethyl-1-cyclohexaneacetic acid), which is a very well known agent useful for the treatment of epilepsy and other cerebral disorders. In the chemical series of 1-amino methyl cyclo alkane-1-acetic acids, Gabapentin, which is 1-amino methyl cyclo hexane-1-acetic acid has been developed as a drug having anti convulsive properties.

  该发明涉及一种改进的氨甲基环烷基乙酸的制备方法。该发明特别涉及一种改进的加巴喷丁（化学上称为1-氨甲基-1-环己烷乙酸）的制备方法，加巴喷丁是一种用于治疗癫痫和其他脑部疾病的非常知名的药物。在1-氨甲基环烷基-1-乙酸化学系列中，加巴喷丁（即1-氨甲基环己烷-1-乙酸）已被开发为一种具有抗惊厥特性的药物。
• [EN] PROCESS FOR THE PREPARATION OF AMINO METHYL CYCLO ALKANE ACETIC ACIDS<br/>[FR] PROCEDE DE PREPARATION D'ACIDES AMINO-METHYL-CYCLOALCANE ACETIQUES
  申请人：HIKAL LTD

  公开号：WO2004046085A1

  公开（公告）日：2004-06-03

  This invention relates to an improved process for the preparation of amino methyl cyclo alkane acetic acids. This invention particularly relates to an improved process for the preparation of gabapentin (which is chemically known as 1-aminomethyl-1-cyclohexaneacetic acid), which is a very well known agent useful for the treatment of epilepsy and other cerebral disorders. In the chemical series of 1-amino methyl cyclo alkane-1-acetic acids, Gabapentin, which is 1-amino methyl cyclo hexane -1-acetic acid has been developed as a drug having anti convulsive properties.

  这项发明涉及一种改进的氨基甲基环烷基乙酸的制备过程。这项发明特别涉及一种改进的加巴喷丁制备过程（在化学上被称为1-氨基甲基-1-环己烷乙酸），这是一种非常著名的用于治疗癫痫和其他脑部疾病的药物。在1-氨基甲基环烷基-1-乙酸化学系列中，加巴喷丁，即1-氨基甲基环己烷-1-乙酸，已经被开发成一种具有抗惊厥作用的药物。
• PROCESS FOR THE PREPARATION OF AMINO METHYL CYCLO ALKANE ACETIC ACIDS
  申请人：Hikal Ltd.

  公开号：EP1603863B1

  公开（公告）日：2010-01-13
• US4152326A
  申请人：——

  公开号：US4152326A

  公开（公告）日：1979-05-01
• US7635717B2
  申请人：——

  公开号：US7635717B2

  公开（公告）日：2009-12-22